Palbace 125mg Tablet
Prescription Required
Product introduction
Palbace 125mg Tablet is used to treat patients with certain types of breast cancer (estrogen receptor-positive, human epidermal growth factor receptor 2-negative) which have spread to other organs. It is given together with hormonal anticancer therapies.
Palbace 125mg Tablet should be taken with food, but try to have it at the same time every day to get the most benefits. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.
Some common side effects of this medicine include fatigue, hair loss, rash, vomiting, and diarrhea. This medicine may reduce the number of blood cells (decrease red blood and white blood cells) in your blood, thereby, increasing the susceptibility to infections. It is better to inform your doctor if you notice symptoms of infection like fever, chills, and weakness, bleeding or bruising and nose bleed. It might also cause dizziness if it happens avoid driving or attention-seeking activities.
Before taking it, tell your doctor if you have heart disease, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.
Palbace 125mg Tablet should be taken with food, but try to have it at the same time every day to get the most benefits. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.
Some common side effects of this medicine include fatigue, hair loss, rash, vomiting, and diarrhea. This medicine may reduce the number of blood cells (decrease red blood and white blood cells) in your blood, thereby, increasing the susceptibility to infections. It is better to inform your doctor if you notice symptoms of infection like fever, chills, and weakness, bleeding or bruising and nose bleed. It might also cause dizziness if it happens avoid driving or attention-seeking activities.
Before taking it, tell your doctor if you have heart disease, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.
Uses of Palbace Tablet
Side effects of Palbace Tablet
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Palbace
- Decreased blood cells (red cells, white cells, and platelets)
- Fatigue
- Hair loss
- Rash
- Vomiting
- Diarrhea
- Nausea
- Decreased appetite
- Infection
- Stomatitis (Inflammation of the mouth)
- Anemia (low number of red blood cells)
- Weakness
- Fever
- Decreased white blood cell count
How to use Palbace Tablet
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Palbace 125mg Tablet is to be taken with food.
How Palbace Tablet works
Palbace 125mg Tablet is an anti-cancer medication. Cyclin dependent kinase 4 and 6
(chemical messengers) are downstream of signaling pathways which lead to the proliferation of cells. This medicine works by inhibiting cyclin dependent kinase 4 and 6, thus arrests the cancer cell cycle (cell growing process). It also targets the estrogen (hormone) receptor-positive breast cancer cells by disrupting the cell cycle.
Safety advice
Alcohol
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Palbace 125mg Tablet. Please consult your doctor.
Pregnancy
CONSULT YOUR DOCTOR
Palbace 125mg Tablet is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
Breast feeding
UNSAFE
Palbace 125mg Tablet is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
Driving
UNSAFE
Palbace 125mg Tablet may cause side effects which could affect your ability to drive.
It may cause fatigue in some people. If this happens, you should exercise caution when driving or using machines.
It may cause fatigue in some people. If this happens, you should exercise caution when driving or using machines.
Kidney
SAFE IF PRESCRIBED
Palbace 125mg Tablet is safe to use in patients with kidney disease. No dose adjustment of Palbace 125mg Tablet is recommended.
Liver
CAUTION
Palbace 125mg Tablet should be used with caution in patients with liver disease. Dose adjustment of Palbace 125mg Tablet may be needed. Please consult your doctor.
All substitutes
For informational purposes only. Consult a doctor before taking any medicines.
Palbace 125mg Tablet
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Quick tips
- Take it with food, preferably at the same time every day.
- If you forget to take the medicine or vomit, skip the missed dose and follow a regular schedule. Do not take a double dose to make up missed dose
- Use effective contraception method to prevent pregnancy while taking this medicine.
- It may cause dizziness. Avoid driving or any activity requiring mental focus until you know how it affects you.
- You may be asked for regular blood tests while taking this medication. Inform your doctor if you notice symptoms of infection like fever, chills, and weakness.
- Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.
- Do not stop taking the medication without talking to your doctor first.
- Take it with food, preferably at the same time every day.
- If you forget to take the medicine or vomit, skip the missed dose and follow a regular schedule. Do not take a double dose to make up missed dose
- Use effective contraception method to prevent pregnancy while taking this medicine.
- It may cause dizziness. Avoid driving or any activity requiring mental focus until you know how it affects you.
- You may be asked for regular blood tests while taking this medication. Inform your doctor if you notice symptoms of infection like fever, chills, and weakness.
- Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.
- Do not stop taking the medication without talking to your doctor first.
Fact Box
Chemical Class
Pyridinylpiperazines
Habit Forming
No
Therapeutic Class
ANTI NEOPLASTICS
Action Class
Cyclin-Dependent Kinase Inhibitor
Interaction with drugs
Taking Palbace with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Carbamazepine may reduce blood levels of Palbociclib.
Do not consume Palbociclib with Carbamazepine.
Phenytoin may reduce blood levels of Palbociclib.
Do not consume Palbociclib with Phenytoin.
Phenobarbitone may reduce blood levels of Palbociclib.
Do not consume Palbociclib with Phenobarbitone.
Phenobarbitone may reduce blood levels of Palbociclib.
Do not consume Palbociclib with Phenobarbitone.
Phenytoin may reduce blood levels of Palbociclib.
Do not consume Palbociclib with Phenytoin.
Patient concerns
FAQs
What kind of medicine is Palbace 125mg Tablet?
Palbace 125mg Tablet is an anti-cancer medicine. Palbace 125mg Tablet blocks proteins known as cyclin-dependent kinase inhibitors. Blocking these proteins can slow down the growth of cancer cells and delay the progression of the cancer.
How long do I have to take Palbace 125mg Tablet?
The duration of treatment varies from person to person. Your doctor will decide the number of cycles you need to receive based on your condition, response to treatment and your tolerance to side effects. Your doctor may decrease your dose or stop your treatment temporarily or permanently if you experience certain side effects.
Are the side effects of Palbace 125mg Tablet irreversible?
No, most of the side effects are reversible and disappear when the medicine is stopped. Neutropenia is a well-recognized adverse effect of Palbace 125mg Tablet in which the number of your white blood cells get reduced and your immune system gets weakened. As a result, you may be at greater risk of getting an infection while you are taking Palbace 125mg Tablet. However, this side effect disappears rapidly once you stop taking the medicine.
Does treatment with Palbace 125mg Tablet require monitoring of blood counts?
Yes, blood tests are important since this medicine can lower your blood counts. The regular blood tests check the effect of Palbace 125mg Tablet on your blood cells (white blood cells, red blood cells, and platelets). These tests should be done at the beginning of each chemotherapy cycle, on the 15th day of the first 2 cycles, and as clinically indicated.
How should I take Palbace 125mg Tablet?
Generally, Palbace 125mg Tablet is taken once daily for 21 consecutive days followed by 7 days off treatment to add up a complete cycle of 28 days. Take this medicine with food and at the same time each day. Swallow the whole capsules. Do not open, chew, or crush them. Do not take the capsules that are broken or cracked. If you vomit after taking Palbace 125mg Tablet, do not take another dose and continue your regular dosing schedule.
Do I need to use birth control method while using Palbace 125mg Tablet?
Women of childbearing potential who are receiving Palbace 125mg Tablet and their partners should use adequate contraceptive methods (e.g. double-barrier contraception such as condom and diaphragm). These methods should be used during therapy and for at least 3 weeks after completing therapy for females. Men who are on Palbace 125mg Tablet therapy should use birth control methods for at least 14 weeks after completing the therapy.
Does Palbace 125mg Tablet affect fertility?
Male fertility may be affected during treatment with Palbace 125mg Tablet. Thus, men may consider sperm preservation prior to beginning therapy with Palbace 125mg Tablet.
What are the serious side effects of Palbace 125mg Tablet?
The serious side effects of Palbace 125mg Tablet include shortness of breath, dizziness, weakness, unusual bleeding or bruising or nosebleeds. It may also cause fever, chills or signs of infection and fast, irregular or pounding heartbeat. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment.
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Disclaimer:
Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.References
- Palbociclib. New York, New York: Pfizer Labs; 2015 [revised 31 Mar. 2017]. [Accessed 25 Jun. 2019] (online) Available from:
- Central Drugs Standard Control Organisation (CDSCO). [Accessed 26 Mar. 2019] (online) Available from:
Marketer details
Name: Pfizer Ltd
Address: The Capital, 1802, 18th Floor , Plot No. C-70, ‘G’ Block , Bandra Kurla Complex, Bandra East , Mumbai – 400051.
Country of origin: India
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