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Sitabull-GM IR 2 Tablet

Written By Dr. Sakshi Jain, MS, BDS
Reviewed By Dr. Rajeev Sharma, MBA, MBBS
Last updated on 28 Jan 2026 | 07:40 PM (IST)
Sitabull-GM IR 2 Tablet is a combination of three medicines used to lower blood glucose levels in people with type 2 diabetes mellitus. It is generally prescribed when diet, exercise, and other treatments do not result in adequate glycemic control.
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Gluconorm-GS Forte 2 Tablet
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Sitabull-GM IR 2 Tablet
Sitabull-GM IR 2 Tablet
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Same composition
Gluconorm-GS Forte 2 Tablet
Gluconorm-GS Forte 2 Tablet
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Sitabull-GM IR 2 Tablet image
Sitabull-GM IR 2 Tablet image
Sitabull-GM IR 2 Tablet image
Sitabull-GM IR 2 Tablet image

Product introduction

Sitabull-GM IR 2 Tablet is best taken with food; however, take this medicine regularly and at the same time each day to get maximum benefits. The dose and duration are decided according to your condition and how well you respond to it. The doctor may also monitor your blood sugar levels regularly when you are taking this combination medicine.


Keep taking this medicine even if you feel well or your blood sugar levels are controlled. If stopped abruptly, your blood sugar levels could rise and put you at risk of complications. This medication is only part of a treatment program that should also include a healthy diet, regular exercise, and weight reduction because lifestyle habits play a big part in controlling diabetes.


The most common side effects of Sitabull-GM IR 2 Tablet include nausea, vomiting, gastrointestinal disturbances, and hypoglycemia. Let your doctor know if any of these side effects do not go away or get worse. They may be able to help by adjusting the dosage or by prescribing an alternate medicine.


You should not take Sitabull-GM IR 2 Tablet if you have type 1 diabetes mellitus or acute or chronic metabolic acidosis, including diabetic ketoacidosis. Patients with active bladder cancer or a history of bladder cancer should also not take this medicine. Inform your doctor about all the other medicines that you take as some of them can affect or be affected by this medication. Pregnant or breastfeeding women should also consult their doctors before taking it.

Uses of Sitabull-GM Tablet

Benefits of Sitabull-GM Tablet

Treatment of Type 2 diabetes mellitus
Lowering blood glucose levels is an essential part of managing diabetes as this helps to reduce the risk of serious diabetes-associated complications, such as kidney damage, eye damage, nerve problems, and loss of limbs. Sitabull-GM IR 2 Tablet helps control high blood glucose (sugar) levels. It also reduces the risk of heart diseases like heart attack or stroke. Taking this medicine regularly along with proper diet and exercise will help you live a normal, healthy life.

Side effects of Sitabull-GM Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Sitabull-GM
  • Gastrointestinal disturbance
  • Headache
  • Diarrhea
  • Abdominal pain
  • Hypoglycemia (low blood glucose level)
  • Constipation
  • Vomiting
  • Nausea

How to use Sitabull-GM Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Sitabull-GM IR 2 Tablet should be taken with or after food.

How Sitabull-GM Tablet works

Sitabull-GM IR 2 Tablet is a combination of three antidiabetic medications. Sitagliptin helps to control blood sugar levels by increasing substances (incretins) in the body that make the pancreas release more insulin. It also signals the liver to stop producing sugar (glucose) when there is too much sugar in the blood. Glimepiride lowers blood sugar by causing the pancreas to produce insulin (a natural substance that is needed to break down sugar in the body) and helping the body use insulin efficiently. Metformin decreases the amount of glucose you absorb from your food and the glucose made by the liver. It also increases the body's response to insulin, a natural substance that controls the amount of glucose in the blood (blood sugar levels).

Quick tips

  • Prefer taking Sitabull-GM IR 2 Tablet after a meal or with a snack, as this will reduce the chance of an upset stomach.
  • Sitabull-GM IR 2 Tablet may cause hypoglycemia (low blood sugar level) when used with other antidiabetic medicines, alcohol or if you delay or miss a meal. Always carry some sugary food or fruit juice with you in case you experience hypoglycemia (low blood sugar) symptoms, such as fatigue, dizziness, cold sweats, tremor, and anxiety.
  • If you get unusually thirsty, pass urine more frequently, and feel tired, let your doctor know. These are signs that there is too much sugar in your blood and your dose may need adjusting.
  • Monitor your blood sugar regularly while taking this medicine.
  • Lifestyle changes like low sugar diet, exercising, losing weight, not smoking, and cutting down on alcohol intake may help this medication work better.

Safety advice

Alcohol

Alcohol

UNSAFE
It is unsafe to consume alcohol with Sitabull-GM IR 2 Tablet
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
The safety of Sitabull-GM IR 2 Tablet during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Sitabull-GM IR 2 Tablet may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.
Driving

Driving

CAUTION
Sitabull-GM IR 2 Tablet may cause dizziness or weakness due to changes in blood pressure. Do not drive if these symptoms occur.
Kidney

Kidney

CAUTION
Sitabull-GM IR 2 Tablet should be used with caution in patients with severe kidney disease. Dose adjustment may be needed.
Liver

Liver

UNSAFE
Sitabull-GM IR 2 Tablet is unsafe to use in patients with liver disease and should be avoided.

Frequently asked questions

Sitabull-GM IR 2 Tablet is used to treat type 2 diabetes mellitus in adults when diet and exercise alone or along with other blood sugar-lowering medicines aren’t enough to control blood sugar. It helps lower blood sugar levels, improve insulin response, and reduce the risk of complications from long-term diabetes.
Sitabull-GM IR 2 Tablet should be taken once or twice daily with meals, depending on your doctor's prescription. Taking the medicine with food reduces the chance of stomach upset and lowers the risk of low blood sugar (hypoglycemia).
No. Sitabull-GM IR 2 Tablet is not recommended for patients with severe kidney or liver problems, as it may increase the risk of lactic acidosis, low blood sugar, or medication buildup in the body. Your doctor will assess kidney function before prescribing.
The common side effects of Sitabull-GM IR 2 Tablet may include nausea, upset stomach, diarrhea, or constipation, headache, hypoglycemia (low blood sugar), weight gain, etc. If you experience severe side effects like difficulty breathing, chest pain, or signs of lactic acidosis (e.g., muscle pain, weakness, or dizziness), contact your doctor immediately.
Avoid alcohol while taking Sitabull-GM IR 2 Tablet, as it can increase the risk of side effects like hypoglycemia (low blood sugar) or lactic acidosis (a serious condition caused by metformin present in Sitabull-GM IR 2 Tablet).
You may start noticing improvements in blood sugar levels within a few days. However, it may take a few weeks to months to see the full benefits.
No, do not stop taking Sitabull-GM IR 2 Tablet without consulting your doctor. Stopping the medication abruptly can cause your blood sugar levels to rise again. Always follow your doctor's instructions.
Avoid high-sugar or high-carbohydrate foods, as they can affect blood sugar control; limit alcohol consumption, as it can increase the risk of side effects; and avoid skipping meals, as it may lead to low blood sugar, etc.
While on Sitabull-GM IR 2 Tablet treatment, your doctor may advise you to regularly check fasting and post-meal blood glucose, HbA1c (every 3 months), kidney and liver function tests, vitamin B12 levels, and weight and blood pressure. These help ensure your diabetes is well managed and prevent complications.

Fact Box

Habit Forming

No

Therapeutic Class

ANTI DIABETIC

References

  1. Sitagliptin/metformin HC [Prescribing Information]. Whitehouse Station: Merck & Co., Inc.; 2012. [Accessed 02 Nov. 2023] (online) Available from:
  2. A Multicenter, Randomized, Comparative, Active-Controlled, Double-Blind, Double-Dummy, Phase 3 Study to Assess Efficacy and Safety of Fixed Dose Combination of Sitagliptin Phosphate, Metformin Hydrochloride and Glimepiride Tablets in Comparison to Co- administration of Metformin Hydrochloride and Glimepiride Tablets in Patients with Type 2 Diabetes Mellitus. Protocol No. ICR/21/004, clinical study report dated 3rd July 2023, Sun Pharma Laboratories Limited, Data on file.
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Lenn Pharmaceuticals
Address: 1/439-1 RANGASWAMY STREET, NGGO COLONY, COIMBATORE - 641022

Vendor Details

Country of origin: India
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