Tofaz 5 Tablet
Prescription Required
Product introduction
Tofaz 5 Tablet is used to treat moderate to severe rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and ulcerative colitis. It helps decrease pain, tenderness, and swelling in the joints by reducing inflammation. It also helps slow the progression of bone and joint damage.
Tofaz 5 Tablet may be prescribed by itself or in combination with another medicine. The tablets can be taken with or without food and it is best to take them at the same time each day. Your dose will depend on your condition and what other medicines you are taking. You should use it as your doctor tells you to. Do not stop taking this medicine unless your doctor tells you to because your condition could get worse.
The most common side effects of Tofaz 5 Tablet include upper respiratory tract infections, headache, diarrhea, and nasopharyngitis. There are other less common side effects, some of them serious, including blood clots and tears in the stomach or intestine wall. These need urgent medical attention. If you have any worries about side effects, talk to your doctor.
You may need blood tests before you are given this medicine and you should not start taking it if you have any kind of infection. Make sure you talk to your doctor before starting treatment if you have or have ever had, tuberculosis, shingles, kidney or liver disease, hepatitis B or C, or blood clots in your legs or lungs. Tofaz 5 Tablet can make you more likely to get infections or may worsen any current infections so avoid contact with people who have things you might catch (such as chickenpox, measles, flu). This medicine is not suitable for children under 18 years old and you should not use it if you are pregnant or breastfeeding, unless your doctor feels the benefit is greater than the risk. Your doctor may need to examine you regularly.
Tofaz 5 Tablet may be prescribed by itself or in combination with another medicine. The tablets can be taken with or without food and it is best to take them at the same time each day. Your dose will depend on your condition and what other medicines you are taking. You should use it as your doctor tells you to. Do not stop taking this medicine unless your doctor tells you to because your condition could get worse.
The most common side effects of Tofaz 5 Tablet include upper respiratory tract infections, headache, diarrhea, and nasopharyngitis. There are other less common side effects, some of them serious, including blood clots and tears in the stomach or intestine wall. These need urgent medical attention. If you have any worries about side effects, talk to your doctor.
You may need blood tests before you are given this medicine and you should not start taking it if you have any kind of infection. Make sure you talk to your doctor before starting treatment if you have or have ever had, tuberculosis, shingles, kidney or liver disease, hepatitis B or C, or blood clots in your legs or lungs. Tofaz 5 Tablet can make you more likely to get infections or may worsen any current infections so avoid contact with people who have things you might catch (such as chickenpox, measles, flu). This medicine is not suitable for children under 18 years old and you should not use it if you are pregnant or breastfeeding, unless your doctor feels the benefit is greater than the risk. Your doctor may need to examine you regularly.
Uses of Tofaz Tablet
- Treatment of Rheumatoid arthritis
- Treatment of Psoriatic arthritis
- Treatment of Ankylosing spondylitis
- Treatment of Ulcerative colitis
Benefits of Tofaz Tablet
In Treatment of Rheumatoid arthritis
Tofaz 5 Tablet works by blocking the action of some chemicals which cause inflammation. It can help reduce pain, stiffness, and swelling in your joints and slow down the progression of bone and joint damage. This will help you do normal daily activities more easily and thus improve your quality of life. This medicine should be taken at the same time each day to get maximum benefits. Keep taking the medicine even if you feel well because it is preventing future harm as well as improving your symptoms.
In Treatment of Psoriatic arthritis
Psoriatic arthritis is a form of arthritis that affects some people who have psoriasis, a condition where the skin cells in the body grow too quickly and form scales and dry patches. Psoriatic arthritis is a type of inflammatory arthritis. Symptoms include joint pain, stiffness and swelling, which may flare and subside. Tofaz 5 Tablet helps reduce pain, stiffness, and swelling associated with the condition. It also helps improve flexibility and prevents the disease progression. This way it helps in the management of psoriatic arthritis and enhances patients' quality of life.
In Treatment of Ankylosing spondylitis
Ankylosing spondylitis is a rare type of arthritis that affects the spine or larger joints. It usually starts in your lower back and can spread up to your neck or damage joints in other parts of your body. Tofaz 5 Tablet helps reduce pain, stiffness and swelling in your spine and joints. It helps improve flexibility and prevents disease progression. This will help you lead a better and active life.
In Treatment of Ulcerative colitis
Ulcerative colitis is a disease of the large intestine (colon) and rectum in which the lining of the bowel becomes red and swollen. This can lead to bleeding, frequent diarrhea and abdominal pain. It relieves these symptoms and also helps you to stay well by preventing them from coming back. Drink plenty of fluids while on treatment with this medicine and stay hydrated.
Side effects of Tofaz Tablet
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Tofaz
- Upper respiratory tract infection
- Headache
- Diarrhea
- Nasopharyngitis (inflammation of the throat and nasal passages)
How to use Tofaz Tablet
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Tofaz 5 Tablet may be taken with or without food, but it is better to take it at a fixed time.
How Tofaz Tablet works
Tofaz 5 Tablet is a Janus kinase inhibitor. It works by blocking the action of the enzyme, Janus kinase. This decreases the activity of the immune system and inflammation associated with rheumatic diseases and ulcerative colitis.
Safety advice
Alcohol
SAFE
Consuming alcohol with Tofaz 5 Tablet does not cause any harmful side effects.
Pregnancy
CONSULT YOUR DOCTOR
Tofaz 5 Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Breast feeding
CONSULT YOUR DOCTOR
Tofaz 5 Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Driving
SAFE
Tofaz 5 Tablet does not usually affect your ability to drive.
Kidney
CAUTION
Tofaz 5 Tablet should be used with caution in patients with severe kidney disease. Dose adjustment of Tofaz 5 Tablet may be needed. Please consult your doctor.
Liver
CAUTION
Tofaz 5 Tablet should be used with caution in patients with severe liver disease. Dose adjustment of Tofaz 5 Tablet may be needed. Please consult your doctor.
What if you forget to take Tofaz Tablet?
If you miss a dose of Tofaz 5 Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
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For informational purposes only. Consult a doctor before taking any medicines.
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Quick tips
- Tofaz 5 Tablet is used alone or in combination with other medicines for the treatment of rheumatoid arthritis, that did not improve with other anti-rheumatic drugs.
- It may take take 3 to 6 months to feel the maximum effect of this medication. Keep taking it as prescribed.
- Your doctor may get regular blood tests done to monitor your liver function, kidney function, blood counts, or cholesterol levels.
- Tofaz 5 Tablet can make it a bit harder for people to fight off infections. Inform your doctor if you have symptoms of an infection such as fever, chills, cough, and muscle aches.
- Your doctor may get TB (tuberculosis) skin test and a chest X-ray before starting treatment with this medication.
- Inform your doctor if you are pregnant, planning to conceive, or breastfeeding.
Fact Box
Chemical Class
Pyrrolo Pyrimidine Derivative
Habit Forming
No
Therapeutic Class
PAIN ANALGESICS
Action Class
Janus kinase inhibitors
Interaction with drugs
Taking Tofaz with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Concurrent use may increase the risk of infections.
Do not use Tofacitinib with Herpes Zoster / Shingles Vaccine (Recombinant, Adjuvanted).
Ciclosporin may raise blood levels of Tofacitinib.
Do not consume Tofacitinib with Ciclosporin.
Bosentan may reduce blood levels of Tofacitinib.
Do not consume Tofacitinib with Bosentan.
Concurrent use may result in loss of efficacy of Tofacitinib. Carbamazepine may reduce blood levels of Tofacitinib.
Do not consume Tofacitinib with Carbamazepine.
Concurrent use may increase the risk of infections.
Do not use Tofacitinib with Cholera Vaccine (Inactivated).
Patient concerns
FAQs
Can I take Tofaz 5 Tablet if I have liver problems?
Inform your doctor if you have liver problems, before starting Tofaz 5 Tablet. This is done because in some cases Tofaz 5 Tablet may cause an increase in liver enzymes. Therefore, your liver function needs to be investigated before starting Tofaz 5 Tablet. Although, Tofaz 5 Tablet can be given to patients with mild to moderate liver function impairment, but should not be prescribed to patients with severe liver impairment.
Can Tofaz 5 Tablet cause cancer?
Tofaz 5 Tablet may increase the chances of developing the risk of certain cancers (lymphoma and other cancers including skin cancers) by affecting the working of the immune system. Hence, inform your doctor if you ever had or have any type of cancer.
What is Tofaz 5 Tablet used for?
Tofaz 5 Tablet is approved for use in people with moderate to severe rheumatoid arthritis. It is an inflammatory disease of the joints. It is used if previous therapy did not work well or did not suit the patient. However, it can also be used earlier in treatment if the person does not respond well to the prescribed drugs. It can be used alone or together with some other medicines, such as methotrexate.
How long does it take for Tofaz 5 Tablet to start working?
Tofaz 5 Tablet usually takes about 2 to 8 weeks before you start feeling better, and it can take 3 to 6 months to feel the maximum effect of this medication.
Do I need to get any investigations done before starting Tofaz 5 Tablet?
You may need to get your blood tests done before you start Tofaz 5 Tablet or while you are taking it. Blood tests are done in order to check if you have a low red blood cell count (anemia), low white blood cell count (neutropenia or lymphopenia), high blood fat (cholesterol) or high levels of liver enzymes. It also helps to ensure that treatment with Tofaz 5 Tablet is not causing problems. In addition to this, your doctor may advise you to get tested for tuberculosis before starting Tofaz 5 Tablet, as using Tofaz 5 Tablet may make an existing infection worse.
Can Tofaz 5 Tablet cause infections?
Tofaz 5 Tablet is a medicine that affects your immune system. This may reduce your ability to fight infection and may increase the risk of getting a serious infection including tuberculosis. It may also include infections caused by severe fungal, bacterial or viral infections that spread through the body. In some cases, these infections can be life-threatening and may even cause death. Hence, it is advised to treat these infections in a hospital.
If I am already taking tocilizumab, can I take Tofaz 5 Tablet?
No, you should not take tocilizumab along with Tofaz 5 Tablet. Tofaz 5 Tablet affects the immune system, so you should avoid taking it with any other immunity-affecting medicine. Taking both medicines together can further increase the risk of infection and may lead to further complications.
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Disclaimer:
Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.References
- Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1373-74.
- Tofacitinib. New York, New York: Pfizer Labs; 2012 [revised Nov. 2012]. [Accessed 02 Apr. 2019] (online) Available from:
- Central Drugs Standard Control Organisation (CDSCO). Tofacitinib. [Accessed 02 Apr. 2019] (online) Available from:
- Tofacitinib [Prescribing Information]. New York, NY: Pfizer labs; 2022. [Accessed 07 Aug. 2023]. (online) Available from:
Marketer details
Name: Forman Medics Pvt Ltd
Address: 53, Ambika Industrial Estate, Near Vatva Railway Over Bridge, Vatva,Ahmedabad - 382440.
Country of origin: India
The list of available options shown with the same composition has been prepared upon the advice of registered medical practitioners, pharmacists affiliated with TATA 1MG. TATA 1MG does not promote any pharmaceutical product of any particular company, and all recommendations are based on the medical opinion, advisories from specialist medical and pharmaceutical professionals.
The list of available options shown with the same composition has been prepared upon the advice of registered medical practitioners, pharmacists affiliated with TATA 1MG. TATA 1MG does not promote any pharmaceutical product of any particular company, and all recommendations are based on the medical opinion, advisories from specialist medical and pharmaceutical professionals.
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