Tolvapil 30mg Tablet is a medicine used in the treatment of low levels of sodium in the blood. It treats low levels of sodium in the blood, which can result from conditions such as heart failure, cirrhosis, and syndrome of inappropriate antidiuretic hormone (SIADH).

Tolvapil 30mg Tablet can be taken with or without food. It should be taken exactly as prescribed by your doctor. Your doctor will decide the dose and how often you should take them. You should take this medicine regularly to get the most benefit from it. Do not stop taking the medicine even if you feel better unless the doctor tells you so.

Using this medicine may cause few common side effects such as frequent urge to urinate, nocturia (increased urge to urinate during the night), dryness in mouth, increased thirst, nausea, increased blood creatinine, hyperkalemia, and constipation. Let your doctor know if any of these side effects do not go away with time or get worse. Before using this medicine, inform your doctor if you have any problems with your kidneys or liver. While on this medicine, your doctor will closely monitor the sodium levels in your blood. You should also tell your doctor all the other medications you are taking.

Uses of Tolvapil Tablet

Treatment of Low levels of sodium in the blood
Syndrome of inappropriate antidiuretic hormone secretion (SIADH)

Benefits of Tolvapil Tablet

In Treatment of Low levels of sodium in the blood

Low levels of sodium may be caused due to multiple reasons such as excess of body fluids, heart disease, and kidney problems. There may be many symptoms such as nausea, headache confusion and the person may even need to get hospitalized. Tolvapil 30mg Tablet helps to get rid of the excess fluids and retains sodium in the blood. This restores the normal sodium levels in our body and prevents further complications such as memory loss.

Side effects of Tolvapil Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Tolvapil

Frequent urge to urinate
Nocturia (increased urge to urinate during the night)
Dryness in mouth
Increased thirst
Constipation
Nausea
Increased creatinine level in blood
Increased potassium level in blood

How to use Tolvapil Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Tolvapil 30mg Tablet may be taken with or without food, but it is better to take it at a fixed time.

How Tolvapil Tablet works

Tolvapil 30mg Tablet is a vasopressin antagonist. It works by blocking the effect of the hormone vasopressin in the body. This increases urine production, reduces the amount of water in the blood and raises the blood sodium level.

Safety advice

Alcohol

CAUTION

Caution is advised when consuming alcohol with Tolvapil 30mg Tablet. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

Tolvapil 30mg Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Breast feeding

CONSULT YOUR DOCTOR

Tolvapil 30mg Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

Driving

UNSAFE

Tolvapil 30mg Tablet may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Kidney

SAFE IF PRESCRIBED

Tolvapil 30mg Tablet is safe to use in patients with kidney disease. No dose adjustment of Tolvapil 30mg Tablet is recommended.
However, the use of Tolvapil 30mg Tablet is not recommended in patients with severe kidney disease.

Liver

CAUTION

Tolvapil 30mg Tablet should be used with caution in patients with liver disease. Dose adjustment of Tolvapil 30mg Tablet may be needed. Please consult your doctor.
Use of Tolvapil 30mg Tablet is not recommended in patients with severe liver disease.

What if you forget to take Tolvapil Tablet?

If you miss a dose of Tolvapil 30mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.

Tolvapil 30mg Tablet

₹95.8/Tablet

Natrise 30 Tablet

Sun Pharmaceutical Industries Ltd

₹271.25/tablet

183% costlier

Resodim 30 Tablet

Lupin Ltd

₹308.75/tablet

222% costlier

Tolvat 30 Tablet

MSN Laboratories

₹294.5/tablet

207% costlier

Tvaptan 30 Tablet

Centaur Pharmaceuticals Pvt Ltd

₹267/tablet

179% costlier

Tolvasca 30 Tablet

Glenmark Pharmaceuticals Ltd

₹278.75/tablet

191% costlier

View all substitutes

Quick tips

Tolvapil 30mg Tablet treats low sodium levels in the blood.
It also improves urine flow without causing the body to lose too much sodium as you urinate.
Take it at the same time everyday. Take it according to the dose and duration prescribed by your doctor.
To avoid dehydration, it is best to drink something as soon as you feel thirsty, but avoid alcoholic drinks.
Do not take Tolvapil 30mg Tablet if you are unable to urinate, if you are unable to tell when you are thirsty, or if you are severely dehydrated.
You will need to be in a hospital under observation any time you start or restart treatment with Tolvapil 30mg Tablet.
Inform your doctor if you notice problems with speech or muscle control, trouble swallowing, trouble moving your arms and legs, or mood changes.
Your doctor may check your liver function before starting treatment and regularly thereafter. Inform your doctor if you notice yellowing of eyes or skin, dark urine, or stomach pain.

Fact Box

Chemical Class

Benzazepine Derivative

Habit Forming

Therapeutic Class

UROLOGY

Action Class

Vasopressin Antagonists

Interaction with drugs

Taking Tolvapil with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Aliskiren (Oral Route) Moderate

Tolvaptan may raise blood levels of Aliskiren. If concurrent use is essential, please consult your doctor.

Mifepristone (Oral Route) Moderate

Mifepristone may raise blood levels of Tolvaptan. Do not consume Mifepristone with Tolvaptan. If concurrent use is essential, watch out for symptoms such as weight gain, dizziness... More

Digoxin (Oral Route) Moderate

Digoxin may raise blood levels of the active form of Tolvaptan. watch out for symptoms of Digoxin side effects such as impaired vision, skin rash, nausea, vomiting, diarrhea or di... More

Fexofenadine (Oral Route) Moderate

Tolvaptan may raise blood levels of Fexofenadine. If concurrent use is essential, please consult your doctor.

Loperamide (Oral Route) Moderate

Tolvaptan may raise blood levels of Loperamide. If concurrent use is essential, please consult your doctor.

View all drug interactions

Patient concerns

I'm having tegrital 200mg daily for last 6 years. Is there any problem having this medicine?

Dr. Vikas Sharma

Neurology

can cause fall in sodium levels. rarely, rash and fall in blood counts

Sodium level of blood drops frequently

Dr. Ankur Kumar Tanwar

Ayurveda

Ok send me your all reports

I am very tensed . My parathyroid hormone is very high . PTH - 110.4 . Please help me and suggest me proper medicines . Please advice me as soon as possible . I am also facing respiratory problems , for that i am consulting a doctor but for PTH please help me .

Dr. Sanjay Bhatt

Physician

In primary hyperparathyroidism, an enlargement of one or more of the parathyroid glands causes overproduction of the hormone, resulting in high levels of calcium in the blood (hypercalcemia), which can cause a variety of health problems. Surgery is the most common treatment for primary hyperparathyroidism

We are doing treatment on nephrotic-syndrome for my daughter. I need a list of food items which she can have in this period also fruit names pls.

Dr. Gopal Bansilal Samdani

Paediatrics

A healthy diet for Nephrotic Syndrome patients consists of low salt, low fat and low cholesterol, with emphasis on fruits and vegetables.Foods that can be taken: Cow's milk, skimmed milk Yogurt Wheat, cereals, sprouts, pulses and legumes such as tur dal, moong dal, rajmah, chana, lentils (masoor), etc. Eggs, fish, dry fish, chicken, lean meat, etc. Vegetables and fruits Soups, sauces, chocolate drinks, juices, etc (but with low sodium content) Wafers, popcorns, chutneys which are prepared in less salt. Moderate to low intake of vegetable oils, butter and mayonnaise. Noodles, spaghetti, pancakes, etc (low in salt)

FAQs

What is the most important information I need to be aware of while taking Tolvapil 30mg Tablet?

Tolvapil 30mg Tablet may cause the level of sodium in your blood to increase too quickly. This quick increase in sodium levels [osmotic demyelination syndrome (ODS)] may cause serious nerve damage, which can further cause coma and even death. The symptoms of ODS could be trouble in speaking, trouble in swallowing or a feeling of food or liquid getting stuck while swallowing, drowsiness, confusion, mood changes, fits, trouble controlling body movement (involuntary movement) and weakness in muscles of the arms and legs.

For how long do I need to take Tolvapil 30mg Tablet?

Tolvapil 30mg Tablet is used for correction of sodium levels in blood. Though the dose and duration are prescribed by the doctor, Tolvapil 30mg Tablet should not be taken for more than 30 days. Once the sodium levels return to normal, it can be stopped after talking to the doctor.

Does Tolvapil 30mg Tablet affect the sugar levels in blood?

Yes, Tolvapil 30mg Tablet may increase the blood sugar levels. Therefore, patients with diabetes mellitus need to be extra careful while taking Tolvapil 30mg Tablet and should keep a check on blood sugar levels regularly.

Who should not take Tolvapil 30mg Tablet?

You should not take Tolvapil 30mg Tablet if you have low sodium levels, cannot replace fluids by drinking or if you cannot tell when you are thirsty, dizzy or feeling faint or if your kidneys are not working properly because of excessive loss of fluids. You should also avoid Tolvapil 30mg Tablet if your body is not able to make urine, you are allergic to Tolvapil 30mg Tablet or if you are on certain medicines which interfere with the working of Tolvapil 30mg Tablet.

Can I have grapefruit juice while taking Tolvapil 30mg Tablet?

No, you should not take grapefruit or grapefruit juice while on Tolvapil 30mg Tablet. The reason being, grapefruit or grapefruit juice may increase the levels of Tolvapil 30mg Tablet in your blood and your sodium levels may rise too quickly.

What will happen if I take excess of Tolvapil 30mg Tablet?

You may need urgent medical attention. Call your doctor or seek emergency service at a nearby hospital. Symptoms of taking too much Tolvaptan may include thirst, dry and flaky skin, sunken eyes, rapid heartbeat, rapid and shallow breathing, very low blood pressure, passing more urine than normal and fainting.

Show less

Related lab tests

Anti Diuretic Hormone

Want to share the information?

Disclaimer:

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

Reilly RF, Jackson EK. Regulation of Renal Function and Vascular Volume. In: Brunton LL, Chabner BA, Knollmann BC,12th ed. editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 714.
Masters SB. Hypothalamic & Pituitary Hormones. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 659.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1379-80.
Tolvaptan. Otsuka Pharmaceutical Co.; 2009 [revised Apr. 2013]. [Accesses 04 Apr. 2019] (online) Available from:
ScienceDirect. Tolvaptan. [Accessed 04 Apr. 2019] (online) Available from:
PubChem. Tolvaptan. [Accessed 04 Apr. 2019] (online) Available from:
Tolvaptan. Wexham, UK: Otsuka Pharmaceuticals (UK) Ltd.; 2015 [revised Feb. 2019]. [Accessed 22 Feb. 2019] (online) Available from:
Tolvaptan [Product Label]. Mumbai, Maharashtra: Alkem Labs Limited; 2019. [Accessed 07 Aug. 2023]. (online) Available from:
Rangarajan B, Binoy V, Hingmire SS, Noronha V. Tolvaptan. South Asian J Cancer. 2014 Jul;3(3):182-4. [Accessed 07 Aug. 2023]. (online) Available from:

Marketer details

Name: Ekard Life Sciences Pvt Ltd

Address: # 7-1-497, Monda Market Bandimetta Secunderabad Hyderabad,Telangana-500003 India

Country of origin: India

The list of available options shown with the same composition has been prepared upon the advice of registered medical practitioners, pharmacists affiliated with TATA 1MG. TATA 1MG does not promote any pharmaceutical product of any particular company, and all recommendations are based on the medical opinion, advisories from specialist medical and pharmaceutical professionals.