Topotel 2.5mg Injection is used in the treatment of ovarian cancer. It shows its working by stopping or slowing down the growth of cancer cells.

Topotel 2.5mg Injection is given as an IV infusion into vein by a qualified medical professional. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.

The most common side effects of this medicine include tiredness, vomiting, weakness, nausea, and abdominal pain. This medicine may reduce the number of blood cells (decrease red blood and white blood cells) in your blood, thereby, increasing the susceptibility to infections. Inform your doctor if you notice fever, chills, sore throat, and severe diarrhea. Regular blood tests are required to check your blood cells along with heart, liver, and blood uric acid levels.

Before taking it, tell your doctor if you have heart disease, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.

Uses of Topotel Injection

Ovarian cancer

Benefits of Topotel Injection

In Ovarian cancer

Ovarian cancer is a cancer that begins in the female organs that produce eggs (ovaries). This type of cancer is usually detected very late and can be fatal too. It usually spreads to the pelvis and stomach. Topotel 2.5mg Injection kills or stops the growth of cancer cells and also prevents the multiplication of cancer cells. It is an effective medicine but has some side effects that may be bothersome. Consult your doctor to know about ways that can help you avoid these side effects.

Side effects of Topotel Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Topotel

Tiredness
Vomiting
Weakness
Nausea
Abdominal pain
Indigestion
Decreased white blood cell count
Decreased blood cells (red cells, white cells, and platelets)
Diarrhea
Injection site reactions (pain, swelling, redness)

How to use Topotel Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Topotel Injection works

Topotel 2.5mg Injection is an anti-cancer medication. It works by suppressing the activity of an enzyme (topoisomerase I) involved in DNA multiplication of the cancer cells. This slows the growth of cancer cells and eventually kills them.

Safety advice

Alcohol

SAFE

Consuming alcohol with Topotel 2.5mg Injection does not cause any harmful side effects.

Pregnancy

CONSULT YOUR DOCTOR

Topotel 2.5mg Injection is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.

Breast feeding

UNSAFE

Topotel 2.5mg Injection is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

Driving

UNSAFE

Topotel 2.5mg Injection may cause side effects which could affect your ability to drive.
Topotel 2.5mg Injection can make you feel tired and this may affect your ability to drive.

Kidney

CAUTION

Topotel 2.5mg Injection should be used with caution in patients with kidney disease. Dose adjustment of Topotel 2.5mg Injection may be needed. Please consult your doctor.
Use of Topotel 2.5mg Injection is not recommended in patients with end-stage kidney disease.

Liver

SAFE IF PRESCRIBED

Topotel 2.5mg Injection is safe to use in patients with liver disease. No dose adjustment of Topotel 2.5mg Injection is recommended.

What if you forget to take Topotel Injection?

If you miss a dose of Topotel 2.5mg Injection, please consult your doctor.\n

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.

Topotel 2.5mg Injection

₹4361/Injection

Topotec 2.5mg Injection

United Biotech Pvt Ltd

₹5978/injection

33% costlier

Cantop 2.5mg Injection

Dr Reddy's Laboratories Ltd

₹4430.15/injection

2% cheaper

Topocan 2.5mg Injection

Venus Remedies Ltd

₹5000/injection

11% costlier

Topowin 2.5mg Injection

Nelwin Lifesciences

₹5000/injection

11% costlier

Quick tips

Topotel 2.5mg Injection helps treat ovarian cancer.
It is given by a drip into a vein (intravenous infusion).
Do not drive or operate machinery as Topotel 2.5mg Injection may cause tiredness, drowsiness or weakness.
Use a reliable contraceptive method to prevent pregnancy while you are taking this medicine.
Your doctor may get regular blood tests done to monitor your blood cells during treatment with this medicine.
Inform your doctor immediately if you notice any signs of infection such as fever, sore throat, rash or severe diarrhea.

Fact Box

Chemical Class

Camptothecin Derivative

Habit Forming

Therapeutic Class

ANTI NEOPLASTICS

Action Class

Topoisomerase Inhibitor

Patient concerns

ovarian cancer stage 3 c surgery done chemotheraphy done

Dr. Aanchal Maheshwari

Ayurveda

C?se has to be seen in person before starting the treatment

My mother dignosis with stage4 ovarian cancer, 1st done on 24th of may 16, I need a alternative medicine parallelly

Dr. Manju Singh

Homeopathy

I would like to recommend you that please continue your treatment as advice by your doctor.

Doctor, I am married since last one month. I have started taking Saheli contraceptive pill ( Ormeloxifene / Centchroman 30 mg) bi-weekly dose since 18th December 2016 which was the first day of my period. Normally my periods was with 28 days interval and 4 days span. My next periods was on 17th January which was 2 days late from scheduled. I first made sex on 5th Feb 2017. Since then I have no periods . I also have checked pregnancy at home with preganews kit which result was negative. Now my periods is almost 18 days late. I want to know is it the normal side effects of saheli or I need further consultation or check up?

Dr. Sonu Balhara Ahlawat

Obstetrics and Gynaecology

Ovarian cyst may occur

FAQs

Q. How often is Topotel 2.5mg Injection given?

Generally Topotel 2.5mg Injection treatment is for 4 cycles of 21 day each, patient is given Topotel 2.5mg Injection for first 5 days of each cycle.

Q. Does Topotel 2.5mg Injection cause hair loss?

Yes, Topotel 2.5mg Injection may cause temporary hair loss.

Q. Does Topotel 2.5mg Injection cause flare reaction?

Yes, Topotel 2.5mg Injection may cause flare reaction.

Q. How long does Topotel 2.5mg Injection take to work?

Topotel 2.5mg Injection may start its action once the infusion is started, however, the complete effect may be assessed only after completion of 4 cycles.

Q. Is Topotel 2.5mg Injection a vesicant?

Topotel 2.5mg Injection is a vesicant (irritant).

Q. Is Topotel 2.5mg Injection effective?

Yes Topotel 2.5mg Injection is effective if used at prescribed doses for the prescribed duration as advised by your doctor.

Q. What is Topotel 2.5mg Injection chemotherapy?

It is a treatment therapy that includes Topotel 2.5mg Injection with or without combination of other drugs in treatment of cancer (Usually ovarian or lung cancer).

Q. How is Topotel 2.5mg Injection administered?

Topotel 2.5mg Injection is either administered orally as a capsule or as an intravenous Infusion in the arm over a period of 30 min.

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

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Chu E, Sartorelli AC. Cancer Chemotherapy. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 951.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. p. 1383.
Topotecan hydrochloride. Camberley, Surrey: Novartis Pharmaceuticals UK Ltd.; 1996 [revised 23 Apr. 2018]. [Accessed 24 Jan. 2019] (online) Available from:
Topotecan. Unterach, Austria: Ebewe Pharma; 1996 [revised Feb. 2014]. [Accessed 27 Mar. 2019] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 27 Mar. 2019] (online) Available from:
Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Topotecan. [Updated 2018 Dec 3]. [Accessed 19 Feb. 2020] (online) Available from:

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