Topotel 2.5mg Injection
Prescription Required
Product introduction
Topotel 2.5mg Injection is used in the treatment of ovarian cancer. It shows its working by stopping or slowing down the growth of cancer cells.
Topotel 2.5mg Injection is given as an IV infusion into vein by a qualified medical professional. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.
The most common side effects of this medicine include tiredness, vomiting, weakness, nausea, and abdominal pain. This medicine may reduce the number of blood cells (decrease red blood and white blood cells) in your blood, thereby, increasing the susceptibility to infections. Inform your doctor if you notice fever, chills, sore throat, and severe diarrhea. Regular blood tests are required to check your blood cells along with heart, liver, and blood uric acid levels.
Before taking it, tell your doctor if you have heart disease, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.
Topotel 2.5mg Injection is given as an IV infusion into vein by a qualified medical professional. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.
The most common side effects of this medicine include tiredness, vomiting, weakness, nausea, and abdominal pain. This medicine may reduce the number of blood cells (decrease red blood and white blood cells) in your blood, thereby, increasing the susceptibility to infections. Inform your doctor if you notice fever, chills, sore throat, and severe diarrhea. Regular blood tests are required to check your blood cells along with heart, liver, and blood uric acid levels.
Before taking it, tell your doctor if you have heart disease, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.
Uses of Topotel Injection
Benefits of Topotel Injection
In Ovarian cancer
Ovarian cancer is a cancer that begins in the female organs that produce eggs (ovaries). This type of cancer is usually detected very late and can be fatal too. It usually spreads to the pelvis and stomach. Topotel 2.5mg Injection kills or stops the growth of cancer cells and also prevents the multiplication of cancer cells. It is an effective medicine but has some side effects that may be bothersome. Consult your doctor to know about ways that can help you avoid these side effects.
Side effects of Topotel Injection
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Topotel
- Tiredness
- Vomiting
- Weakness
- Nausea
- Abdominal pain
- Indigestion
- Decreased white blood cell count
- Decreased blood cells (red cells, white cells, and platelets)
- Diarrhea
- Injection site reactions (pain, swelling, redness)
How to use Topotel Injection
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Topotel Injection works
Topotel 2.5mg Injection is an anti-cancer medication. It works by suppressing the activity of an enzyme (topoisomerase I) involved in DNA multiplication of the cancer cells. This slows the growth of cancer cells and eventually kills them.
Safety advice
Alcohol
SAFE
Consuming alcohol with Topotel 2.5mg Injection does not cause any harmful side effects.
Pregnancy
CONSULT YOUR DOCTOR
Topotel 2.5mg Injection is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
Breast feeding
UNSAFE
Topotel 2.5mg Injection is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
Driving
UNSAFE
Topotel 2.5mg Injection may cause side effects which could affect your ability to drive.
Topotel 2.5mg Injection can make you feel tired and this may affect your ability to drive.
Topotel 2.5mg Injection can make you feel tired and this may affect your ability to drive.
Kidney
CAUTION
Topotel 2.5mg Injection should be used with caution in patients with kidney disease. Dose adjustment of Topotel 2.5mg Injection may be needed. Please consult your doctor.
Use of Topotel 2.5mg Injection is not recommended in patients with end-stage kidney disease.
Use of Topotel 2.5mg Injection is not recommended in patients with end-stage kidney disease.
Liver
SAFE IF PRESCRIBED
Topotel 2.5mg Injection is safe to use in patients with liver disease. No dose adjustment of Topotel 2.5mg Injection is recommended.
What if you forget to take Topotel Injection?
If you miss a dose of Topotel 2.5mg Injection, please consult your doctor.\n
All substitutes
For informational purposes only. Consult a doctor before taking any medicines.
Topotel 2.5mg Injection
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Quick tips
- Topotel 2.5mg Injection helps treat ovarian cancer.
- It is given by a drip into a vein (intravenous infusion).
- Do not drive or operate machinery as Topotel 2.5mg Injection may cause tiredness, drowsiness or weakness.
- Use a reliable contraceptive method to prevent pregnancy while you are taking this medicine.
- Your doctor may get regular blood tests done to monitor your blood cells during treatment with this medicine.
- Inform your doctor immediately if you notice any signs of infection such as fever, sore throat, rash or severe diarrhea.
Fact Box
Chemical Class
Camptothecin Derivative
Habit Forming
No
Therapeutic Class
ANTI NEOPLASTICS
Action Class
Topoisomerase Inhibitor
Interaction with drugs
Taking Topotel with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Concurrent use may cause a decrease in the ability of the bone marrow to produce blood cells.
Do not consume Topotecan from 1 day before until 1 day after taking Molgramostim. Ple
Concurrent use may cause a decrease in the ability of the bone marrow to produce blood cells.
Do not consume Topotecan from 14 days before until 24 days after taking Pegfilgrastim
Concurrent use may cause a decrease in the ability of the bone marrow to produce blood cells.
Do not consume Topotecan from 1 day before until 1 day after taking Sargramostim. Ple
Concurrent use may cause a decrease in the ability of the bone marrow to produce blood cells.
Do not consume Lenograstim from 24 hours before until 24 hours after undergoing cytot
Concomitant use may increase the risk of opportunistic infections.
Do not consume Natalizumab with Topotecan.
Patient concerns
FAQs
How often is Topotel 2.5mg Injection given?
Generally Topotel 2.5mg Injection treatment is for 4 cycles of 21 day each, patient is given Topotel 2.5mg Injection for first 5 days of each cycle.
Does Topotel 2.5mg Injection cause hair loss?
Yes, Topotel 2.5mg Injection may cause temporary hair loss.
Does Topotel 2.5mg Injection cause flare reaction?
Yes, Topotel 2.5mg Injection may cause flare reaction.
How long does Topotel 2.5mg Injection take to work?
Topotel 2.5mg Injection may start its action once the infusion is started, however, the complete effect may be assessed only after completion of 4 cycles.
Is Topotel 2.5mg Injection a vesicant?
Topotel 2.5mg Injection is a vesicant (irritant).
Is Topotel 2.5mg Injection effective?
Yes Topotel 2.5mg Injection is effective if used at prescribed doses for the prescribed duration as advised by your doctor.
What is Topotel 2.5mg Injection chemotherapy?
It is a treatment therapy that includes Topotel 2.5mg Injection with or without combination of other drugs in treatment of cancer (Usually ovarian or lung cancer).
How is Topotel 2.5mg Injection administered?
Topotel 2.5mg Injection is either administered orally as a capsule or as an intravenous Infusion in the arm over a period of 30 min.
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Disclaimer:
Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.References
- Chabner BA, Bertino J, Cleary J, et al. Cytotoxic Agents. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1711-12.
- Chu E, Sartorelli AC. Cancer Chemotherapy. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 951.
- Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. p. 1383.
- Topotecan hydrochloride. Camberley, Surrey: Novartis Pharmaceuticals UK Ltd.; 1996 [revised 23 Apr. 2018]. [Accessed 24 Jan. 2019] (online) Available from:
- Topotecan. Unterach, Austria: Ebewe Pharma; 1996 [revised Feb. 2014]. [Accessed 27 Mar. 2019] (online) Available from:
- Central Drugs Standard Control Organisation (CDSCO). [Accessed 27 Mar. 2019] (online) Available from:
- Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Topotecan. [Updated 2018 Dec 3]. [Accessed 19 Feb. 2020] (online) Available from:
Marketer details
Name: Fresenius Kabi India Pvt Ltd
Address: Fresenius Kabi AG , Else-Kröner-Straße 1 , 61352 Bad Homburg , Germany
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