Trofentyl 50mcg Injection

Reviewed By Dr. Sachin Gupta, MD Pharmacology, MBBS

Last updated on 14 Apr 2026 | 04:21 PM (IST)

Trofentyl 50mcg Injection is a pain-relieving medicine. It is used to treat moderate to severe pain. It is also used as an anesthetic agent for short surgical procedures. This medicine should not be used in mild pain.

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General Information

Contains

Fentanyl (50mcg)

Marketer

Troikaa Pharmaceuticals Ltd.

Storage

Store below 30°C

The content is shown in English

Product introduction

Trofentyl 50mcg Injection is administered by a healthcare professional. You should not self-administer this medicine at home. The dose will depend on what you are taking it for and how well it helps your symptoms.

The most common side effects of this medicine include muscle rigidity, nausea, and vomiting. You may also experience other common side effects such as dizziness, sleepiness, increased or decreased blood pressure, and irregular heartbeat. If any of these side effects persist or get worse, you should let your doctor know. Your doctor may be able to suggest ways of preventing or reducing the symptoms.

Before using it, you should let your doctor know if you have respiratory disorders, heart diseases, high blood pressure, and liver or kidney disease. Let your doctor also know about all the other medicines you are taking because they may affect, or be affected by, this medicine. Pregnant and breastfeeding women should consult their doctors before using the medicine.

Uses of Trofentyl Injection

Pain relief

Benefits of Trofentyl Injection

Pain relief
Trofentyl 50mcg Injection helps to relieve moderate to severe pain in conditions that affect joints and muscles. It works by blocking chemical messengers in the brain that tell us we have pain. It can help relieve pain in conditions like rheumatoid arthritis and osteoarthritis.
It is given as an injection by a doctor or nurse and should not be self-administered. The dose and duration will be decided by the doctor depending on the condition you are being treated for. This will help you to go about your daily activities more easily and have a better, more active, quality of life.

Side effects of Trofentyl Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Trofentyl

Muscle rigidity
Irregular heartbeats
Dizziness
Vomiting
Nausea
Drowsiness
Application site redness
Respiratory depression
Rigidity

How to use Trofentyl Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Trofentyl Injection works

Trofentyl 50mcg Injection is an opoid analgesic (pain reliever) which works by blocking transmission of pain signals to the brain to lower pain perception.

Quick tips

Trofentyl 50mcg Injection helps provide pain relief during surgery.
It is given by an injection or drip into a vein.
It may cause dizziness, sleepiness, and headaches. Do not drive or do anything requiring concentration until you know how it affects you.
Do not drink alcohol or take other medicines that can cause drowsiness while taking Trofentyl 50mcg Injection.
Your doctor may monitor your breathing, blood pressure and heart rate while you receive this medication.
Inform your doctor if you have ever been diagnosed with kidney or liver problems.

Safety advice

Alcohol

UNSAFE

It is unsafe to consume alcohol with Trofentyl 50mcg Injection

Pregnancy

CONSULT YOUR DOCTOR

Trofentyl 50mcg Injection is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.

Breast feeding

CAUTION

Trofentyl 50mcg Injection should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from the body.
Consult a doctor immediately if the baby shows signs of increased sleepiness (more than usual), difficulty breastfeeding, breathing problems, or limpness.

Driving

UNSAFE

Trofentyl 50mcg Injection may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Kidney

CAUTION

Trofentyl 50mcg Injection should be used with caution in patients with kidney disease. Dose adjustment may be needed.
Caution should be excercised in patients with underlying kidney disease.

Liver

CAUTION

Trofentyl 50mcg Injection should be used with caution in patients with liver disease. Dose adjustment may be needed.

Interaction with drugs

Taking Trofentyl with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Life-threatening

Selegiline (Oral Route)

Do not consume Selegiline with Fentanyl. If essential, watch out for symptoms such as fever, tremors, diarrhea or agitation. Please consult your doctor.

Life-threatening

Naltrexone (Oral Route)

Do not consume Naltrexone with Fentanyl; watch out for symptoms such as breathlessness, increased heart rate, or headache. Naltrexone may reduce efficacy of Fentanyl.

Life-threatening

Tranylcypromine (Oral Route)

Do not consume Tranylcypromine with Fentanyl. If Tranylcypromine is essential, ensure a gap of At least 2 weeks between taking Tranylcypromine and Fentanyl. Please consult your doctor.

Severe

Ziprasidone (Oral Route)

Watch out for symptoms such as tremors, fever, diarrhea or agitation and consult your doctor if you experience them. Your doctor may discontinue the medicines accordingly.

Severe

Alprazolam (Oral Route)

If concurrent use is essential, watch out for symptoms of Alprazolam side effects such as drowsiness, excessive sedation, tiredness, dizziness or slurred speech and consult your doctor if you experience them. They may adjust the dose of Alprazolam as per the observations. It is advised to avoid driving or undertaking other tasks requiring skill and alertness.

Fact Box

Chemical Class

Phenylpiperidine Derivatives

Habit Forming

Yes

Therapeutic Class

PAIN ANALGESICS

Action Class

Opioids

References

Schumacher MA, Basbaum AI, Way WL. Opioids Analgesics & Antagonists. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 545-46.
Yaksh TL, WallaceIn MS. Opioids, Analgesia, and Pain Management. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 505-506.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 539-41.
Fentanyl. Gloucester Business Park Gloucester: Hameln Pharmaceuticals Ltd.; 10 Jan. 2011 [revised 28 Oct. 2018]. [Accessed 02 Apr. 2019] (online) Available from:
Chaves RG, Lamounier JA. Breastfeeding and maternal medications. J Pediatr (Rio J). 2004;80(5 Suppl):S189-S198. [Accessed 02 Apr. 2019] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 02 Apr. 2019] (online) Available from:

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Troikaa Pharmaceuticals Ltd.
Address: Troikaa Pharmaceuticals Ltd., Registered Office: , 'Commerce House - 1', Satya Marg, Bodakdev, Ahmedabad-380 054. Gujarat, India.

Vendor Details

Country of origin: India

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Trofentyl 50mcg Injection

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General Information

Contains

Marketer

Storage

Product introduction

Uses of Trofentyl Injection

Benefits of Trofentyl Injection

Side effects of Trofentyl Injection

How to use Trofentyl Injection

How Trofentyl Injection works

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Selegiline (Oral Route)

Naltrexone (Oral Route)

Tranylcypromine (Oral Route)

Ziprasidone (Oral Route)

Alprazolam (Oral Route)

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

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