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Tyvalzi Combipack Injection

Sovateltide (30mcg)
Genuine
Authenticity Assured
Prescription
required
Cold stored
Stored between 2-8°C
Tyvalzi Combipack Injection is a prescription medicine used for the treatment of ischemic stroke. It works by activating specific receptors in the brain that help enhance blood flow and oxygen delivery to the affected brain areas. This helps in healing the brain and speed up recovery.

Written By Dr. Syeda Aafia, MBA, BDS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 23 Jan 2026 | 10:15 AM (IST)
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General Information

Contains

Sovateltide (30mcg)

Marketer

Sun Pharmaceutical Industries Ltd

Storage

Store in a refrigerator (2 - 8°C). Do not freeze.
The content is shown in English
Tyvalzi Combipack Injection image
Tyvalzi Combipack Injection image
Tyvalzi Combipack Injection image

Product introduction

Tyvalzi Combipack Injection is generally administered as an injection by a doctor or a nurse, typically in a hospital or clinical setting. To ensure the best outcomes from the treatment, follow the doctor’s instructions regarding the dosing schedule. Complete the full course of treatment as prescribed and do not skip any doses.


Tyvalzi Combipack Injection is generally safe and well-tolerated; no common side effects were reported at the recommended dose. However, it may cause some headaches, nausea, dizziness, and fatigue in some people. If these side effects occur, contact your doctor for advice. They may suggest ways to manage these symptoms or adjust the treatment plan.


Before you receive this medicine, let your doctor know if you have a known history of allergy to any medications. Let your doctor also know about any other medications or supplements you are taking if any. Patients should avoid using other medications, particularly anticoagulants and antiplatelet drugs, unless prescribed by the doctor. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss their situation with their doctor, as the safety of Tyvalzi Combipack Injection in these scenarios is not well established.

Uses of Tyvalzi Injection

Benefits of Tyvalzi Injection

Treatment of Ischemic stroke
In an ischemic stroke, a blood clot blocks blood flow to the brain. Tyvalzi Combipack Injection helps by improving blood flow and oxygen supply to the damaged parts of the brain, which supports the healing process. This can speed up recovery and help the patients regain their brain function more quickly. Tyvalzi Combipack Injection reduces the risk of long-term effects of a stroke and improves the patient's overall quality of life.

Side effects of Tyvalzi Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Tyvalzi
  • No common side effects seen

How to use Tyvalzi Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Tyvalzi Injection works

Tyvalzi Combipack Injection works by activating endothelin-B (ETB) receptors in the brain. This stimulates neural progenitor cells (immature brain cells that can grow into new neurons), helping repair brain damage after a stroke. It promotes the growth of new nerve cells and blood vessels (neurovascular remodeling), improves blood flow in the brain, prevents cell death (anti-apoptotic effect), and protects the energy-producing parts of brain cells (mitochondria) while supporting their regeneration.

Quick tips

  • Tyvalzi Combipack Injection is a first-in-class drug to treat acute cerebral ischemic stroke.
  • It can be given up to 24 hours after the onset of symptoms.
  • It should be used only under the supervision of a specialist.

Safety advice

Alcohol

Alcohol

CAUTION
Alcohol should be used with caution while taking Tyvalzi Combipack Injection.
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
The safety of Tyvalzi Combipack Injection during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Tyvalzi Combipack Injection may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.
Driving

Driving

CONSULT YOUR DOCTOR
It is not known whether Tyvalzi Combipack Injection alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Please consult your doctor.
Kidney

Kidney

CONSULT YOUR DOCTOR
There is limited data available on the use of Tyvalzi Combipack Injection in patients with kidney disease. Please consult your doctor.
Liver

Liver

SAFE IF PRESCRIBED
Tyvalzi Combipack Injection is safe to use in patients with liver disease. No dose adjustment is recommended.

Frequently asked questions

Tyvalzi Combipack Injection is a medication used to treat ischemic stroke. It helps improve blood flow and oxygen delivery to the brain, aiding in the recovery and repair of brain cells damaged by the stroke.
Tyvalzi Combipack Injection works by activating specific receptors in the brain known as endothelin B receptors. This activation helps increase blood flow and oxygen to the affected areas of the brain, promoting healing and recovery.
Tyvalzi Combipack Injection is given as an injection by a healthcare professional, usually in a hospital or clinical setting.
Tyvalzi Combipack Injection is prescribed for patients who have experienced an ischemic stroke. Your doctor will determine if it is the right treatment for you based on your medical condition and history.
Follow your doctor’s instructions carefully. Attend all scheduled appointments, complete the full course of treatment, and inform your doctor about any other medications or supplements you are taking.
You should inform your doctor about all other medications or supplements you are taking. Some drugs, especially blood thinners, may interact with Tyvalzi Combipack Injection.
The safety of Tyvalzi Combipack Injection during pregnancy or breastfeeding is not well established. If you are pregnant, planning to become pregnant, or breastfeeding, discuss this with your doctor before starting treatment.

Fact Box

Chemical Class

Peptides

Habit Forming

No

Therapeutic Class

NEURO CNS

Action Class

Selective endothelin-B (ETB) receptor agonist

References

  1. Keam SJ. Sovateltide: First Approval. Drugs. 2023;83(13):1239-1244. [Accessed 27 June 2024] (online) Available from:
  2. Gulati A, Agrawal N, Vibha D, et al. Safety and Efficacy of Sovateltide (IRL-1620) in a Multicenter Randomized Controlled Clinical Trial in Patients with Acute Cerebral Ischemic Stroke. CNS Drugs. 2021;35(1):85-104. [Accessed 27 June 2024] (online) Available from:
  3. Anil G, Sikandar A, Pamidimukkala V, et al. Sovateltide (Tycamzzi) in patients with cerebral ischemic stroke. A randomized multicenter study. Critical Care Medicine. 2023;51(1):252. [Accessed 27 June 2024] (online) Available from:
  4. Press Release: Sun Pharma and Pharmazz Inc. enter into licensing agreement for introducing Tyvalziâ„¢ (Sovateltide) in India. [Accessed 27 June 2024] (online) Available from:
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Sun Pharmaceutical Industries Ltd
Address: Plot no 107/108,Namli block , Ranipool, East Sikkim 737135 || Khasra No. 1335-1340,Near EPIP- I, Vill - Bhatoli Kalan ,Baddi, Solan, Himachal Pradesh, 173205

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Tyvalzi Combipack Injection. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's â„ž and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India

Lab tests offered by us

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Most medicines cannot be sold without a valid prescription, as per the Drugs and Cosmetics Act, 1940 and Rules, 1945
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