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MDS, BDS
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MBA, MD Pharmacology
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MMST, MBBS
Reviewed By
MBA, MBBS
Last updated
12 Apr 2025 | 12:25 AM (IST)

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Zeesaz 500 Tablet DR

Prescription Required

Product introduction

Zeesaz 500 Tablet DR is a medicine used to treat various inflammatory conditions, including rheumatoid arthritis and psoriatic arthritis (joints), ulcerative colitis, and Crohn’s disease (bowel). It reduces swelling and inflammation by blocking certain chemicals in the body.

Zeesaz 500 Tablet DR may be taken with or without food. Take it regularly and at the same time each day to get the maximum benefit from it. Keep taking it as recommended by your doctor and complete the dose even if you feel better. Drinking plenty of water while taking it can help prevent kidney issues, including kidney stones.


Common side effects of Zeesaz 500 Tablet DR include nausea, headache, vomiting, and gastrointestinal discomfort. You should consult with your doctor if any of these side effects do not resolve with time or get worse. Your doctor may help with ways to reduce or prevent these symptoms.


To ensure Zeesaz 500 Tablet DR is safe for you, let your doctor know if you have any heart, kidney, or liver problems. Additionally, inform your doctor about all other medications you are currently taking. Your doctor may recommend regular blood tests to check your kidney and liver functions and blood components. Pregnant and breastfeeding mothers should seek medical advice before using this medicine.


Benefits of Zeesaz Tablet DR

In Treatment of Rheumatoid arthritis

In individuals with rheumatoid arthritis, Zeesaz 500 Tablet DR helps slow joint damage and reduce pain and swelling. It also helps improve mobility and makes daily activities easier by decreasing joint inflammation.

In Treatment of Psoriatic arthritis

In psoriatic arthritis, Zeesaz 500 Tablet DR helps reduce joint pain, stiffness, and swelling. It also helps protect the joints from long-term damage and may also improve skin symptoms associated with psoriasis.

In Treatment of Ulcerative colitis

In individuals with ulcerative colitis, Zeesaz 500 Tablet DR helps control inflammation in the colon, reducing symptoms like diarrhea, rectal bleeding, and stomach cramps. It can also help maintain long-term remission and improve overall digestive comfort.

In Treatment of Crohn’s disease

Crohn's disease is a chronic inflammatory bowel disease (IBD) that affects the digestive tract. Zeesaz 500 Tablet DR helps reduce inflammation in the digestive tract, which can relieve symptoms of Crohn’s disease like diarrhea, stomach pain, and fatigue. Controlling inflammation also helps prevent flare-ups and improve overall gut health.

Side effects of Zeesaz Tablet DR

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Zeesaz

  • Gastrointestinal discomfort
  • Headache
  • Nausea
  • Oligospermia (low sperm count)
  • Vomiting

How to use Zeesaz Tablet DR

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Zeesaz 500 Tablet DR is to be taken with food.

How Zeesaz Tablet DR works

Zeesaz 500 Tablet DR is a Disease Modifying Anti-Rheumatoid Drug (DMARD). It works by suppressing the overactivity of the immune system in autoimmune diseases and blocking the chemical messengers that cause inflammation (swelling).

Safety advice

Alcohol
UNSAFE
It is unsafe to consume alcohol with Zeesaz 500 Tablet DR.
Pregnancy
SAFE IF PRESCRIBED
Zeesaz 500 Tablet DR is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
Breast feeding
CONSULT YOUR DOCTOR
Zeesaz 500 Tablet DR is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Driving
SAFE
Zeesaz 500 Tablet DR does not usually affect your ability to drive.
Kidney
CAUTION
Zeesaz 500 Tablet DR should be used with caution in patients with kidney disease. Dose adjustment of Zeesaz 500 Tablet DR may be needed. Please consult your doctor.
Regular monitoring of kidney function tests is advisable while you are taking this medicine.
Liver
UNSAFE
Zeesaz 500 Tablet DR is probably unsafe to use in patients with liver disease and should be avoided. Please consult your doctor.

What if you forget to take Zeesaz Tablet DR?

If you miss a dose of Zeesaz 500 Tablet DR, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.
Zeesaz 500 Tablet DR
₹3.0/Tablet DR
SSN 500 Tablet DR
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₹4.07/tablet dr
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SSZ 500mg Tablet DR
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₹8.16/tablet dr
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₹4.66/tablet dr
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Conisazz 500mg Tablet DR
Novalab Healthcare Pvt Ltd
₹4.23/tablet dr
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Sufy 500mg Tablet DR
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₹4.51/tablet dr
50% costlier

Quick tips

  • Zeesaz 500 Tablet DR may take 6-8 weeks to show effects. Continue taking it as prescribed.
  • Drink plenty of fluids while taking Zeesaz 500 Tablet DR to help prevent kidney issues, including kidney stones.
  • Do not take Zeesaz 500 Tablet DR if you have an allergy to sulfa drugs or aspirin.
  • Zeesaz 500 Tablet DR may cause your skin, urine, saliva, and tears to appear orange or yellow in color. This is normal and not harmful.
  • Regular blood tests are necessary while taking this medicine to monitor liver function, kidney function, and blood component levels.
  • Do not stop taking the medication suddenly without talking to your doctor.

Fact Box

Chemical Class
Aminosalicylic Acids Derivative
Habit Forming
No
Therapeutic Class
GASTRO INTESTINAL
Action Class
Non-Biologic DMARDs (Disease Modifying Anti-Rheumatoid Drugs)

Interaction with drugs

Taking Zeesaz with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Please consult with your doctor. Doctor may monitor liver function and blood cell counts. Concurrent use may increase the risk of serious side effects of Methotrexate.
Please consult with your doctor. Doctor may monitor liver function and blood cell counts. Concurrent use may increase the risk of serious side effects of Methotrexate.
Please consult with your doctor. Doctor may monitor liver function and blood cell counts. Concurrent use may increase the risk of serious side effects of Methotrexate.
Please consult with your doctor. Doctor may monitor liver function and blood cell counts. Concurrent use may increase the risk of serious side effects of Methotrexate.
Your doctor may monitor your blood cell count and adjust the doses as per the observations. Concurrent use may increase the risk of low blood cell counts.

Patient concerns

Sir/Ma'am, I feel pain in the heel of both the legs especially when I get up from the bed in the morning. After walking couple of steps, it goes away. there is no bone problem reported in the Xray report. Please guide me what could be the reason?
Dr. Mehtab Baig
Orthopaedic Physiotherapy
This is the test for rheumatoid arthritis
What is gatheya. What is it solution
Dr. Akshat Goel
Orthopaedics
It is supposed to be Rheumatoid Arthritis

FAQs

What is Zeesaz 500 Tablet DR, and what is it used for?

Zeesaz 500 Tablet DR belongs to a group of medicines called anti-inflammatory agents. It is used to treat various inflammatory conditions such as Crohn’s disease, rheumatoid arthritis, ulcerative colitis, and psoriatic arthritis.

Is Zeesaz 500 Tablet DR a steroid or a painkiller?

Zeesaz 500 Tablet DR is neither a steroid nor a painkiller. It is an anti-inflammatory medicine. It is used to treat and manage ulcerative colitis and Crohn's disease, in which the intestines become inflamed (swelling of intestines). It is also used to treat rheumatoid arthritis (painful joint disease).

I have been prescribed Zeesaz 500 Tablet DR for rheumatoid arthritis. When can I expect the pain in my joints to be better?

Zeesaz 500 Tablet DR does not work right away. It takes about 6 to 12 weeks to deliver the full effect. You may start feeling better in 4 weeks after starting Zeesaz 500 Tablet DR, but it can vary from person to person, and some of the patients may notice improvement after 3 months. Consumption of medicine should not be stopped without consulting your doctor.

For how long do I need to take Zeesaz 500 Tablet DR?

If you can tolerate Zeesaz 500 Tablet DR, which means the side effects do not bother you, then you have to continue Zeesaz 500 Tablet DR till the disease remains in remission. It is better to take Zeesaz 500 Tablet DR for the prescribed period.

Does the use of Zeesaz 500 Tablet DR for the treatment of arthritis affect kidney function?

Though it is uncommon, Zeesaz 500 Tablet DR may affect your kidney function. Therefore, your kidney function must remain normal before you start taking Zeesaz 500 Tablet DR. If your kidney functions become abnormal during the treatment, consult your doctor.

Do I need to get any blood tests done while on Zeesaz 500 Tablet DR therapy?

Your doctor will advise blood tests to check your blood cell counts and your kidney function before starting your treatment and regularly during treatment. The tests should also be done to measure substances produced by your liver, known as enzymes (liver function tests), and urine for protein and blood before you start treatment and at regular intervals.

Can Zeesaz 500 Tablet DR affect my fertility?

Decreased sperm count and infertility have been reported in some males. These may disappear once the Zeesaz 500 Tablet DR is discontinued.

Can I take azathioprine along with Zeesaz 500 Tablet DR?

You should avoid using Zeesaz 500 Tablet DR with azathioprine since there are chances of a decrease in blood cell count, which can be a serious side effect.

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

  1. Furst DE, Ulrich RW, Varkey-Altamirano C. Nonsteroidal Anti-Inflammatory Drugs, Disease Modifying Antirheumatic Drugs, Nonopioids Analgesics, & Drugs Used in Gout. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 632-33.
  2. Sulfasalazine [EMC Label]. Sandwich, Kent: Pfizer Limited; 2010 [revised Feb. 2014]. [Accessed 23 Jan. 2019] (online) Available from: External Link
  3. Sulfasalazine [Patient Information Leaflet]. Uppsala, Sweden: Recipharm, Uppsala; 2018. [Accessed 18 Jun. 2019] (online) Available from: External Link
  4. Sulfasalazine [Prescribing Information]. New York, New York: Pharmacia & Upjohn Co.; 2014. [Accessed 18 Jun. 2019] (online) Available from: External Link
  5. Choi J, Fenando A. Sulfasalazine. [Updated 2022 Nov 11]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023. [Accessed 06 Aug. 2023]. (online) Available from: External Link
  6. National Health Service. Sulfasalazine. [Accessed 06 Aug. 2023]. (online) Available from: External Link
  7. Sulfasalazine [Drug Information Booklet]. [Accessed 06 Aug. 2023]. (online) Available from External Link

Marketer details

Name: Zeelab Pharmacy Pvt Ltd
Address: 913, D-Mall,Netaji Subhash Place Pitampura New Delhi New Delhi DL 110034 IN
Country of origin: India

MRP
45
Inclusive of all taxes
15.0 Tablet DR in 1 strip
SOLD OUT

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