Metformin + Pioglitazone + Sitagliptin

Written By Dr. Subita Alagh

Reviewed By Dr. Rajeev Sharma

Last updated 25 Nov 2025 | 09:37 AM (UTC)

Metformin + Pioglitazone + Sitagliptin Uses

Metformin+Pioglitazone+Sitagliptin is used in the treatment of type 2 diabetes mellitus.

How Metformin + Pioglitazone + Sitagliptin works

Metformin + Pioglitazone + Sitagliptin is a combination of three antidiabetic medications. Metformin decreases the amount of glucose you absorb from your food and the glucose made by the liver. It also increases the body's response to insulin, a natural substance that controls the amount of glucose in the blood (blood sugar levels). Pioglitazone works by enhancing cellular responsiveness to insulin and increasing insulin-dependent glucose utilization and disposal. Sitagliptin helps to control blood sugar levels by increasing substances (incretins) in the body that make the pancreas release more insulin. It also signals the liver to stop producing sugar (glucose) when there is too much sugar in the blood.

Common side effects of Metformin + Pioglitazone + Sitagliptin

Nausea, Vomiting, Diarrhea, Flatulence, Constipation

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Medicine brands for Metformin + Pioglitazone + Sitagliptin

Zuventus Healthcare Ltd

₹185 to ₹185

1 variant(s)

Sitazit-Trio

Glenmark Pharmaceuticals Ltd

₹160 to ₹160

2 variant(s)

Sitarite MP

Eswar Therapeutics Pvt Ltd

₹172 to ₹172

1 variant(s)

Sitara PM

Intas Pharmaceuticals Ltd

₹174 to ₹190

3 variant(s)

Ignalis MP

Intas Pharmaceuticals Ltd

Expert advice for Metformin + Pioglitazone + Sitagliptin

Prefer taking Metformin + Pioglitazone + Sitagliptin after a meal or with a snack, as this will reduce the chance of an upset stomach.
Metformin + Pioglitazone + Sitagliptin may cause hypoglycemia (low blood sugar level) when used with other antidiabetic medicines, alcohol or if you delay or miss a meal. Always carry some sugary food or fruit juice with you in case you experience hypoglycemia (low blood sugar) symptoms, such as fatigue, dizziness, cold sweats, tremor, and anxiety.
If you get unusually thirsty, pass urine more frequently, and feel tired, let your doctor know. These are signs that there is too much sugar in your blood and your dose may need adjusting.
Monitor your blood sugar regularly while taking this medicine.
Lifestyle changes like low sugar diet, exercising, losing weight, not smoking, and cutting down on alcohol intake may help this medication work better.