Anti - Neutrophil Cytoplasmic Antibodies (ANCA) by IFA near me in Mumbai

The MPO (p-ANCA) is a blood test that measures autoantibodies targeting the myeloperoxidase (MPO) enzyme (located in neutrophils). These autoantibodies are associated with autoimmune vasculitis disorders, particularly granulomatosis with polyangiitis (GPA) and other forms of vasculitis, where the immune system mistakenly attacks small blood vessels. This test helps diagnose these diseases, track disease activity, evaluate treatment response, and predict flare-ups.

Active inflammation is typically indicated by high MPO (p-ANCA) levels, while a decline suggests treatment effectiveness. Results should, however, be interpreted alongside clinical symptoms, as not all individuals with these diseases test positive, and false positives may occur with other conditions, such as infections or inflammatory conditions.

The PR3 (c-ANCA) is a blood test that measures the levels of autoantibodies targeting the proteinase 3 (PR3) enzyme (located inside neutrophils). These autoantibodies are associated with autoimmune vasculitis disorders, particularly granulomatosis with polyangiitis (GPA), and other forms of vasculitis, where the immune system mistakenly attacks small blood vessels. This test helps diagnose these diseases, track disease activity, evaluate treatment response, and predict flare-ups.

Active inflammation is usually suggested by high PR3-ANCA levels, whereas a decline in their levels can indicate the effectiveness of treatment. Results should, however, be interpreted in conjunction with clinical symptoms, as not all individuals with these diseases are positive, and false positive results may occur with other conditions such as infections.

The Atypical ANCA (Anti-Neutrophil Cytoplasmic Antibodies) test measures the presence of specific antibodies in the blood that target proteins in neutrophils, a type of white blood cell. These antibodies are often linked to autoimmune conditions such as Churg-Strauss Syndrome, Ulcerative Colitis, autoimmune hepatitis and certain types of vasculitis. Unlike the typical ANCA test, which detects antibodies against proteins like proteinase 3 (PR3) and myeloperoxidase (MPO), the atypical ANCA test looks for antibodies against other antigens. This test is primarily used in diagnosing autoimmune conditions like vasculitis, particularly those that may not show up with other ANCA testing, helping doctors identify and manage these conditions more accurately.