Differential Basophil Count
Understanding Differential Basophil Count
What is Differential Basophil Count?
The Differential Basophil Count test measures the percentage of basophils, a type of white blood cell (WBC), in the blood. This test helps identify certain conditions such as infection, inflammation, allergy, etc. It is often done as part of a complete blood count test that also measures other types of blood cells.
Basophils play a critical part in "immune surveillance". They have the ability to detect and destroy some early cancer cells. Another important function of these cells is that they release the histamine hormone during an allergic reaction or asthma attack.
The Differential Basophil Count test helps check triggering inflammatory reactions in the body. A very high basophil count (basophilia) may signal an infection or a more serious condition, like leukemia or autoimmune disease. Whereas, a low basophil count (basopenia) could signal that your basophils are working overtime to attack an allergen or treat an infection that is taking longer than normal to heal. No special preparation is required for this test; eat or drink as per your daily routine.
Test result ranges are approximate and may differ slightly between different labs depending on the methodology and laboratory guidelines. Talk to your doctor about your specific test results. The results will help them determine your medical condition and formulate an overall treatment plan.
What is Differential Basophil Count used for?
The Differential Basophil Count test can be done:
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As part of a complete blood count test to monitor your overall health.
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To identify the cause of allergies, inflammation, or infections.
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To detect diseases characterized by chronic inflammation.
What does Differential Basophil Count measure?
The Differential Basophil Count test measures the relative percentage of basophils in the blood. Basophils are spherically shaped small cells that originate from bone marrow and make up almost 1% of the total white blood cells in the body. These cells attack a foreign substance and release proteins, like histamine and heparin, to destroy harmful substances like allergens, pathogens, or parasites. Histamine helps widen the blood vessels and make space for more immune cells to come to the site of infection or injury, whereas heparin acts as a blood-thinning agent and helps avoid blood clotting at the infection or injury site.