Test Detail
Understanding the Test
Interpreting Results
Other Tests
Content created by
Written by
Dr. Shreya Gupta
BDS, MDS - Oral and Maxillofacial Pathology
Reviewed by
Dr. Ashish Ranjan
MBBS, MD (Pharmacology)
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Immunofixation Electrophoresis Serum

Also known as M-SPIKE, Serum, Quantitative, Multiple Myeloma Profile, Quantitative
You need to provide
Blood
This test is for
Male, Female
Test Preparation
  1. Overnight fasting is preferred.

Understanding Immunofixation Electrophoresis Serum


What is Immunofixation Electrophoresis Serum?

Immunofixation Electrophoresis (IFX) Serum test measures the levels of specific immunoglobulins (antibodies or proteins produced by the immune system that fight infections), including IgG, IgM, and IgA present in the blood. By identifying specific antibodies, this test helps detect, manage, or monitor plasma cell dyscrasia or multiple myeloma. You may need this test if you experience symptoms such as unexplained fatigue or weight changes, bone pain, loss of appetite, etc. Additionally, anemia, frequent infections, proteinuria, and elevated calcium levels in the blood may also be noted. This test may also help in monitoring treatment efficacy or disease recurrence if you have previously undergone treatment for multiple myeloma or other similar conditions.

What is Immunofixation Electrophoresis Serum used for?

You should get this test done if you have symptoms of plasma cell disorders like 


•    Bone pains 

•    Back pain, especially around the ribs

•    Frequent Infection

•    Pathological fractures 







Interpreting Immunofixation Electrophoresis Serum results


Interpretations

The presence of M spike on electrophoresis is usually indicative of multiple myeloma. 


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