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Rheumatoid Arthritis Package

Also known as Rheumatoid arthritis panel, Rheumatoid arthritis screening, Autoimmune
Rheumatoid Arthritis Package Includes 11 testsView All
971911660 16% Off
You need to provide
Blood
This test is for
Male, Female
Test Preparation
  1. No special preparation is required.

Understanding Rheumatoid Arthritis Package


What is Rheumatoid Arthritis Package?

The Rheumatoid Arthritis Package includes a comprehensive set of blood tests that help in the early diagnosis of rheumatoid arthritis (RA). This package includes specific biomarkers that help in understanding the immune response and inflammation levels in the body.

Rheumatoid arthritis (RA) is a chronic autoimmune (where the immune system attacks healthy cells by mistake) and inflammatory disorder that primarily affects the joints, causing pain, inflammation, swelling , and potential loss of function. Early diagnosis and management are important for preventing joint damage and improving long-term outcomes.

Rheumatoid arthritis test package comprises a range of serological markers and autoantibodies, each playing an important role in understanding the autoimmune activity associated with RA. Key components of this package includes: SS-B/La and SSA-A/Ro52 antibodies that can be present in RA, indicating potential systemic autoimmune activity, ds-DNA and Anti-Nuclear Antibody (ANA) by IFA - End Point Titer helps differentiate RA from other autoimmune disorders like systemic lupus erythematosus (SLE), Anti-citrullinated protein antibodies (ACPAs)/ CP4 series are specific markers for RA, often present in early stages of the disease, IgG (Anti IgM - RF- IgM Detection) is a classical marker that helps diagnose RA and RA33, an autoantigen associated with autoimmune diseases like RA. Together these tests provide a holistic view of the autoimmune and inflammatory responses in the body, guiding doctors tailor treatment strategies effectively. 

The Rheumatoid Arthritis Package is useful for individuals experiencing persistent  joint pain, or stiffness, unexplained fatigue suggestive of the onset of RA or other autoimmune conditions. It is valuable for those with a family history of autoimmune diseases, as well as individuals with known risk factors such as smoking or a history of other inflammatory conditions. This package is also advisable for patients who have been already diagnosed with RA and need to monitor their disease activity or assess the effectiveness of ongoing treatment. 

No special preparation is required before undergoing the Rheumatoid Arthritis Package.Inform your doctor about all the medications and supplements that you may be taking as these may affect the test results potentially requiring adjustments or temporary discontinuation before the test. 

Lab test results may vary across different laboratories. Abnormal test results require an expert interpretation, therefore, never try to self-medicate at home based solely on these results, and always consult a doctor for proper understanding of the test results. Your doctor may suggest lifestyle modifications, including dietary changes, stress management techniques, and ergonomics adjustments for arthritis management.

What is Rheumatoid Arthritis Package used for?

The Rheumatoid Arthritis Package is done: 

  • To detect rheumatoid arthritis (RA) and other autoimmune disorders at an early stage, facilitating prompt treatment
  • To confirm a diagnosis of RA in individuals presenting with signs and symptoms such as pain, warmth, swelling and stiffness in the joints etc.
  • To differentiate RA from other similar autoimmune or inflammatory conditions, such as SLE or Sjorgen’s syndrome
  • To identify individuals with risk factors like family history of arthritis, other inflammatory conditions, etc.
  • To assess the activity and progression of RA in diagnosed patients
  • To monitor the treatment response to RA over time.

What does Rheumatoid Arthritis Package measure?

Contains 11 tests

The Rheumatoid Arthritis (RA) Package measures various biomarkers and antibodies that are indicative of autoimmune activity and inflammation associated with RA. Together, these comprehensive tests provide a detailed overview of the immune system’s activity, helping to diagnose RA, differentiate it from other conditions, and monitor disease progression and treatment effectiveness. 

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SS-B/La

The SS-B/La measures the presence of antibodies against the SS-B antigen in the blood. These antibodies are often associated with autoimmune disorders, particularly Sjorgen's syndrome. This test is used alongside SS-A (Ro) antibody test to help in the diagnosis of Sjogren's syndrome and other autoimmune diseases like Systemic lupus erythematosus (SLE). Detecting SS-B antibodies helps doctors assess autoimmune activity, confirm diagnosis and differentiate between various autoimmune conditions. However, the presence of SS-B antibodies alone is not definitive, and results should be interpreted in conjunction with clinical symptoms and other laboratory findings.

Know more about SS-B/La

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ds-DNA

The ds-DNA test detects the presence of antibodies specifically directed against the genetic material called double-stranded DNA (dsDNA) found in the nucleus of cells. These antibodies are often found in systemic lupus erythematosus (SLE), an autoimmune disease where the immune system mistakenly attacks its own DNA. A positive result means that these antibodies are present, suggesting active disease or flare-ups, especially in the kidneys. A negative result means the antibodies were not found, making SLE less likely but not ruling it out completely. This test helps doctors understand if the disease is active and monitor how well treatments are working.

Know more about ds-DNA

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IgG (Anti IgM - RF- IgM Detection)

The IgG (Anti IgM - RF- IgM Detection) test detects the presence of IgG antibodies that react with IgM antibodies, which are often associated with autoimmune diseases like rheumatoid arthritis. A positive test result means IgG anti-IgM antibodies are detected, suggesting the presence of an autoimmune condition such as rheumatoid arthritis. On the other hand, a negative test result means no IgG anti-IgM antibodies are found, indicating that an autoimmune disease like rheumatoid arthritis is less likely. This test helps doctors understand if the disease is active and monitor how well treatments are working.

Know more about IgG (Anti IgM - RF- IgM Detection)

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SS-A/Ro60

The SS-A/Ro60 test detects antibodies against the Ro60 protein, which is part of the SS-A (Ro) antigen. These antibodies are commonly found in autoimmune conditions like systemic lupus erythematosus (SLE) and Sjögren's syndrome. A positive result for SS-A/Ro60 antibodies suggests an increased likelihood of these autoimmune diseases and may also indicate a higher risk of complications, such as neonatal lupus and congenital heart block in infants born to mothers with these antibodies.  However, a negative result does not completely rule out these autoimmune diseases. Additional tests may be needed to confirm a diagnosis or explore other possible autoimmune conditions.

Know more about SS-A/Ro60

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ACPA/CP4-2

The ACPA/CP4-2 test is a blood test used to detect the presence of anti-citrullinated protein antibodies (ACPA), which are commonly associated with autoimmune diseases like rheumatoid arthritis. These antibodies target proteins that have undergone a process called citrullination, which is often seen in individuals with rheumatoid arthritis. A positive test result means ACPA are detected, suggesting the presence of rheumatoid arthritis or an increased risk of developing it, while a negative result means these antibodies are not present, making the condition less likely. This test helps doctors understand if the disease is active and monitor how well treatments are working.

Know more about ACPA/CP4-2

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ACPA/CP4-3

The ACPA/CP4-3 test is a blood test used to detect the presence of anti-citrullinated protein antibodies (ACPA), which are commonly associated with autoimmune diseases like rheumatoid arthritis. These antibodies target proteins that have been modified by a process called citrullination, which is often seen in individuals with rheumatoid arthritis. A positive test result means ACPA are detected, suggesting the presence of rheumatoid arthritis or an increased risk of developing it, while a negative result means these antibodies are not present, making the condition less likely. This test helps doctors understand if the disease is active and monitor how well treatments are working.

Know more about ACPA/CP4-3

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RA33

The RA33 test used to detect RA33 antibodies, which are autoantibodies that can be present in people with autoimmune diseases, particularly rheumatoid arthritis (RA). RA33 is a type of antibody that targets proteins in the cell's nucleus. It is often found in rheumatoid arthritis (RA) but can also be present in other autoimmune diseases like systemic lupus erythematosus (SLE). Positive result indicates the presence of RA33 antibodies, suggesting a higher likelihood of rheumatoid arthritis or another autoimmune condition. A negative result means these antibodies aren't detected, making RA less likely, although it doesn't completely rule out the disease and may require addition testings for an accurate diagnosis. This test helps doctors diagnose and monitor rheumatoid arthritis or other autoimmune diseases.

Know more about RA33

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ACPA/CP4-4

The ACPA/CP4-4 test used to detect anti-citrullinated protein antibodies (ACPA), which are linked to rheumatoid arthritis (RA). This test specifically looks for antibodies that target proteins modified by citrullination, a process often seen in people with RA. A positive result suggests the presence of RA or an increased risk of developing it. A negative result means these antibodies are not present, making RA less likely, but further testing may be needed to confirm the diagnosis. This test helps doctors diagnose rheumatoid arthritis and monitor how well treatments are working.

Know more about ACPA/CP4-4

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SSA-A/Ro52

The SSA-A/Ro52 test detects antibodies against the Ro52 protein, which is a component of the SS-A (Ro) antigen. These antibodies are commonly associated with autoimmune diseases such as systemic lupus erythematosus (SLE), Sjögren's syndrome, and other connective tissue disorders. A positive result for SSA-A/Ro52 antibodies can help support the diagnosis of these conditions, especially in cases where other tests, like the SS-A/Ro60 test, may not be positive. Additionally, the presence of Ro52 antibodies may be linked to a higher risk of developing complications like neonatal lupus or congenital heart block in babies born to mothers with these antibodies. However, a negative result does not completely rule out these conditions,

Know more about SSA-A/Ro52

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ACPA/CP4-1

The ACPA/CP4-1 test used to detect anti-citrullinated protein antibodies (ACPA), which are associated with rheumatoid arthritis (RA). This test specifically looks for antibodies that target citrullinated proteins, a process that is common in RA. A positive result indicates the presence of ACPA, suggesting the likelihood of rheumatoid arthritis or an increased risk of developing it. A negative result means these antibodies are not found, making RA less likely, but additional testing may be needed for confirmation. This test helps doctors in diagnosing rheumatoid arthritis and monitoring treatment effectiveness.

Know more about ACPA/CP4-1

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Anti-Nuclear Antibody (ANA) by IFA - End Point Titer

An Anti-Nuclear Antibody (ANA) by IFA - End Point Titer test checks for antinuclear antibodies (ANA) in your blood. These antibodies, different from typical ones that fight off invaders in the body, can attach to structures inside the body’s own cell nuclei. If ANAs are present in the blood, it may suggest that your immune system is overly sensitive, causing inflammation against your own tissues and possibly indicating autoimmune diseases. 

Know more about Anti-Nuclear Antibody (ANA) by IFA - End Point Titer

Answers to Patient Concerns & Frequently Asked Questions (FAQs) about Rheumatoid Arthritis Package


Frequently Asked Questions about Rheumatoid Arthritis Package

Q. What is the Rheumatoid Arthritis Package?

Rheumatoid Arthritis (RA) Package is a comprehensive set of blood tests tailored to detect the presence and severity of rheumatoid arthritis.

Q. How is the Rheumatoid Arthritis Package performed?

A phlebotomist (a trained professional to perform blood draws) will clean your skin using an antiseptic alcohol cotton swab or wipe and take blood samples from your vein using a needle. The blood sample will be stored safely and transported to the laboratory for analysis.

Q. Is there any risk associated with the Rheumatoid Arthritis Package?

No, the Rheumatoid Arthritis Package is generally safe with minimal risks. However, you may feel slight discomfort during blood sample collection but chances of serious complications are extremely rare.

Q. Who should consider getting tested with the Rheumatoid Arthritis Package?

Individuals experiencing joint pain, stiffness, and swelling and those at risk of developing arthritis due to family history or other risk factors should consider getting tested with Rheumatoid Arthritis Package.

Q. How often should the Rheumatoid Arthritis Package be done?

The frequency depends on individual circumstances, including whether a person has been diagnosed with arthritis or has risk factors for the disease.

Q. What are the common symptoms of rheumatoid arthritis?

Common symptoms of RA include joint pain, swelling, stiffness (especially in the morning or after periods of inactivity), fatigue, and loss of joint function. Symptoms often affect multiple joints, typically on both sides of the body.

Q. Can arthritis be cured?

There is no cure for arthritis but your doctor will help you find treatments that manage your symptoms.

Q. Can lifestyle changes help manage RA?

Yes, lifestyle changes can help manage RA. Regular exercise, a healthy diet, maintaining a healthy weight, quitting smoking, and stress management can all contribute to reducing symptoms and improving overall health.

Q. How does Tata 1mg ensure accurate lab test results?

Tata 1mg ensures accurate lab test results through certified laboratories that use advanced technology and adhere to stringent quality control measures. This commitment to high standards guarantees reliable results.
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Rheumatoid Arthritis Package test price for other cities


Price inBangaloreRs. 7249
Price inHyderabadRs. 7249
Price inMumbaiRs. 7249
Price inKolkataRs. 9719
Price inNew DelhiRs. 9719
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References

  1. Rheumatoid Arthritis [Internet]. National Institute of Arthritis and Musculoskeletal and Skin Diseases. NIH; Nov. 2022. [Accessed 01 Jul. 2024]. Available from: https://www.niams.nih.gov/health-topics/rheumatoid-arthritis#:~:text=Rheumatoid%20arthritis%20(RA)%20is%20a,loss%20of%20function%20in%20joints.External Link
  2. Rheumatoid Arthritis [Internet]. Atlanta, Georgia: Arthritis Foundation; 15 Oct. 2021 [Accessed 01 Jul. 2024]. Available from: https://www.arthritis.org/diseases/rheumatoid-arthritis External Link
  3. Rheumatoid Factor - an overview [Internet]. ScienceDirect; [Accessed 01 Jul. 2024]. Available from: https://www.sciencedirect.com/topics/medicine-and-dentistry/rheumatoid-factor External Link
  4. Rheumatoid arthritis (RA) [Internet]. CDC; 27 Jul. 2020 [Accessed 01 Jul. 2024]. Available from: https://www.cdc.gov/arthritis/basics/rheumatoid-arthritis.html External Link
  5. Arthritis [Internet]. National Institute of Health: Bethesda, MD; 2023 November 16 [Accessed 01 Jul. 2024]. Available from: https://www.nih.gov/about-nih/what-we-do/nih-turning-discovery-into-health/research-healthy-living/arthritis External Link
  6. Chauhan K, Jandu JS, Brent LH, et al. Rheumatoid Arthritis. [Updated 2023 May 25]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK441999/ External Link
  7. Heidari B. Rheumatoid Arthritis: Early diagnosis and treatment outcomes. Caspian J Intern Med. 2011 Winter;2(1):161-70. PMID: 24024009; PMCID: PMC3766928. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3766928/ External Link
  8. Amaya-Amaya J, Rojas-Villarraga A, Mantilla RD, et al. Rheumatoid arthritis. In: Anaya JM, Shoenfeld Y, Rojas-Villarraga A, et al., editors. Autoimmunity: From Bench to Bedside [Internet]. Bogota (Colombia): El Rosario University Press; 2013 Jul 18. Chapter 24. Available from: https://www.ncbi.nlm.nih.gov/books/NBK459454/ External Link

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