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Nimesulide + Serratiopeptidase is a combination of two medicines: Nimesulide and Serratiopeptidase which relieve pain. Nimesulide is a non-steroidal anti-inflammatory drug (NSAID) which works by blocking the release of certain chemical messengers that cause pain and inflammation (redness and swelling). Serratiopeptidase is an enzyme which works by breaking down abnormal proteins at the site of inflammation, and promotes healing. Nimesulide + Serratiopeptidase is a combination of two medicines: Nimesulide and Serratiopeptidase which relieve pain. Nimesulide is a non-steroidal anti-inflammatory drug (NSAID) which works by blocking the release of certain chemical messengers that cause pain and inflammation (redness and swelling). Serratiopeptidase is an enzyme which works by breaking down abnormal proteins at the site of inflammation, and promotes healing.