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Pioglitazone commonly causes weight gain which may be dose-related. The reason for this weight gain could be fat accumulation. However, in heart failure patients it could be due to water retention in the body. Therefore, it is important to monitor weight in heart failure cases.

Pioglitazone can cause fluid retention which may aggravate or speed up heart failure. The doctor usually starts with the lowest available dose and increases the dose gradually while treating patients who have at least one risk factor for heart failure (previous heart attack, coronary artery disease, elderly). Heart failure is more common when Pioglitazone is used with insulin.

Yes, Pioglitazone can be used with metformin where sufficient blood sugar management was not possible with metformin alone. This combination of medicines can be used in adult patients with type 2 diabetes mellitus and overweight patients with poor blood sugar control.

It is usually prescribed once daily and can be taken at any time of the day but preferably at the same time each day. It can be taken with or without food. You should take Pioglitazone exactly as prescribed by your doctor.

Continue taking Pioglitazone as long as your doctor recommends taking it. Treatment for diabetes mellitus is long-term so you may have to take it lifelong. However, if you have to stop it then consult with your doctor who will suggest an alternative. Do not stop taking it without consulting your doctor as it may cause blood sugar levels to rise, which could be harmful to you.

Pioglitazone may increase the risk of bladder cancer, though it is very rare. Immediately consult your doctor if you experience blood in your urine, pain when urinating or a sudden need to urinate, during treatment with this medicine. Pioglitazone should not be used in patients with a prior history of bladder cancer or having bladder cancer.

Yes, Pioglitazone may cause an increase in liver enzymes, and treatment with Pioglitazone should be stopped if liver enzymes increase. Hence, levels of liver enzymes should be periodically checked while on treatment with this medicine. Pioglitazone should not be prescribed to patients with liver disease.

Pioglitazone belongs to the thiazolidinediones class of anti-diabetic medicines. It helps control blood sugar levels by improving how your body uses a hormone called insulin. This is done by helping your cells become more sensitive to the insulin your body makes.

People with type 2 diabetes are not able to make enough insulin or respond normally to the insulin made by their bodies. When this happens, the concentration of sugar/glucose increases in the blood. Metformin acts in several ways to reduce the increased levels of sugar in blood. Metformin decreases glucose production from the liver and decreases absorption of glucose from the intestine after taking food while improving the sensitivity of the body organs and muscles towards insulin. This helps improve the uptake of glucose from the blood. It also helps your body to respond better to the insulin it makes naturally.

Yes, Metformin has been shown to cause weight loss in people who are overweight or obese. It may also cause a modest loss in weight in those overweight and obese individuals who are at risk for diabetes. In addition, patients who are sensitive or resistant to insulin may also show weight loss. But, do not start taking this medicine for weight loss on your own. Consult your doctor for the same.

Metformin is one of the first medicines that is given to patients with high blood sugar levels. It helps control blood sugar levels. It promotes the body’s response to the insulin made by the pancreas, decreases the amount of sugar made by the liver and decreases the amount of sugar absorbed by the intestines. Unlike other oral antidiabetic medicines, Metformin when taken alone, rarely causes low blood sugar as it prevents the pancreas from secreting more insulin. In addition to being a great medicine to lower blood sugar levels, it also helps in controlling weight gain.

Metformin usually does not cause sleepiness and is well tolerated. However, the use of Metformin may rarely cause sleep disorders and insomnia. Sleepiness may be due to a very serious side effect called lactic acidosis, which particularly occurs if your kidneys are not working properly. Contact your doctor if you feel sleepy or tired while taking Metformin.

Take Metformin with or after a meal. Do not crush or chew the tablets and swallow it with a glass of water. If your doctor has prescribed one tablet a day, prefer taking it in the morning with breakfast. If you have been prescribed two tablets a day, then take one in the morning and other in the evening with dinner. In case of three doses a day, apart from morning and evening, you can take it with lunch. Taking Metformin with meals will reduce its digestive problems like indigestion, nausea, vomiting, diarrhea, stomach ache and loss of appetite.