Lorbriqua 100mg Tablet

Reviewed By Dr. Sachin Gupta, MD Pharmacology, MBBS

Last updated on 08 Apr 2026 | 11:43 AM (IST)

Lorbriqua 100mg Tablet is used to treat adults with unresectable (unremovable), advanced, or recurrent forms of non-small cell lung cancer (NSCLC). It works by inhibiting an enzyme called anaplastic lymphoma kinase (ALK) and is given to patients who have an alteration in this enzyme.

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General Information

Contains

Lorlatinib (100mg)

Marketer

Pfizer Ltd

The content is shown in English

Product introduction

Furthermore, Lorbriqua 100mg Tablet is prescribed only to those patients who no longer respond to other ALK inhibitors, such as alectinib or ceritinib. Additionally, it is also effective in treating ALK-positive NSCLC that has spread to the brain.

Take this medicine with or without food, but preferably at the same time each day. Depending on the condition and response to the treatment, the doctor may alter the dose or stop the treatment for a short time. Continue taking this medicine for as long as the doctor has prescribed, and do not stop suddenly.

Some common side effects of Lorbriqua 100mg Tablet include edema (swelling in arms, legs, hands, and feet), peripheral neuropathy (numbness and tingling feeling in joints, arms, and legs), and cognitive disorders (confusion, forgetfulness, and lack of concentration or attention). It may also cause breathlessness, fatigue, weight gain, joint pain, mood changes, and diarrhea. Consult the doctor if any of these side effects are worrisome or worsen. They may adjust the medicine dose and suggest ways to manage them.

Let the doctor know if you have any medical conditions, such as kidney or heart disease, depression, seizures, problems with the heartbeat, or breathing problems. Also, let them know if you have high blood pressure, high levels of cholesterol, or diabetes before starting the treatment with this medicine. Pregnant or breastfeeding women should also consult their doctor before taking this medicine. Some other medications may affect the working of this tablet; therefore, tell the doctor about all the other medicines you may be taking before starting the treatment with this medicine.

Uses of Lorbriqua Tablet

Treatment of Non-small cell lung cancer

Benefits of Lorbriqua Tablet

Treatment of Non-small cell lung cancer
Lorbriqua 100mg Tablet helps shrink the tumor size and restricts the spread of cancer to other parts of the body. This medicine can effectively treat cancer that has spread to the brain because it can cross the blood-brain barrier. This barrier is a network of blood and tissue that prevents infectious bacteria and other harmful substances from entering the brain. The use of Lorbriqua 100mg Tablet helps prevent disease progression and reduce the chances of recurrence over a long period.

Side effects of Lorbriqua Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Lorbriqua

Diarrhea
Cough
Joint pain
Hypercholesterolemia (high cholesterol)
Weight gain
Fatigue
Edema (swelling)
Mood changes
Peripheral neuropathy (tingling and numbness of feet and hand)
Breathlessness
Cognitive impairment

How to use Lorbriqua Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Lorbriqua 100mg Tablet may be taken with or without food.

How Lorbriqua Tablet works

Lorbriqua 100mg Tablet is an anti-cancer medication. It works by blocking the action of the abnormal protein that signals cancer cells to multiply. This helps to stop or slow the spread of cancer cells.

All substitutes for Lorbriqua 100mg Tablet

For information purposes only. Consult a doctor before taking any medicine.

Lorbriqua 100mg Tablet

by Pfizer Ltd

₹0.07/tablet

100% cheaper

Quick tips

Take Lorbriqua 100mg Tablet at the same time every day to maintain steady levels in your body.
Swallow the medicine whole with water and do not crush, chew, or split it.
Avoid grapefruit or grapefruit juice, as it can increase side effects.
Let your doctor know if you notice mood changes, confusion, or memory problems.
Keep a regular check on your cholesterol and liver levels as advised during Lorbriqua 100mg Tablet treatment.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Lorbriqua 100mg Tablet. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

Lorbriqua 100mg Tablet is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.

Breast feeding

UNSAFE

Lorbriqua 100mg Tablet is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

Driving

UNSAFE

Lorbriqua 100mg Tablet may cause side effects that could affect your ability to drive.

Kidney

CAUTION

Lorbriqua 100mg Tablet should be used with caution in patients with severe kidney disease. Dose adjustment may be needed.

Liver

CAUTION

Lorbriqua 100mg Tablet should be used with caution in patients with severe liver disease. Dose adjustment may be needed.

Interaction with drugs

Taking Lorbriqua with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Severe

Ethinyl Estradiol (Injection Route)

Do not consume Lorlatinib with Ethinyl Estradiol. Lorlatinib may reduce blood levels of Ethinyl Estradiol.

Severe

Phenytoin (Oral Route)

Do not consume Lorlatinib with Phenytoin. Phenytoin may reduce blood levels of Lorlatinib.

Severe

Phenytoin (Injection Route)

Do not consume Lorlatinib with Phenytoin. Phenytoin may reduce blood levels of Lorlatinib.

Severe

Pimozide (Oral Route)

Do not consume Lorlatinib with Pimozide. Lorlatinib may reduce blood levels of Pimozide.

Severe

Primidone (Oral Route)

Do not consume Lorlatinib with Primidone. Primidone may reduce blood levels of Lorlatinib.

Frequently asked questions

What is Lorbriqua 100mg Tablet used for?

Lorbriqua 100mg Tablet is a targeted therapy medicine used to treat non-small cell lung cancer (NSCLC) that has spread to other parts of the body (metastatic). It is specifically for patients whose cancer has a specific genetic mutation called ALK-positive (anaplastic lymphoma kinase-positive).

Is Lorbriqua 100mg Tablet effective for lung cancer patients who have failed previous ALK therapies?

Yes, Lorbriqua 100mg Tablet is especially designed for ALK-positive NSCLC patients whose cancer has worsened despite earlier treatments with ALK inhibitors like crizotinib, ceritinib, or alectinib. It is known for its ability to work even after resistance to these anticancer medicines develops.

Can Lorbriqua 100mg Tablet cause serious mental or mood changes?

Yes, Lorbriqua 100mg Tablet affects your brain and mood. Some patients may experience confusion, memory problems, mood swings, hallucinations, or speech difficulties. Always inform your doctor if you notice unusual changes in thinking, sleep, or behavior.

Is it safe to take Lorbriqua 100mg Tablet if I am pregnant or planning to become pregnant?

No, Lorbriqua 100mg Tablet may harm an unborn baby. Women of childbearing potential should use a non-hormonal birth control method during treatment and for at least 35 days after stopping. Men should also use effective contraception for 14 weeks after stopping Lorbriqua 100mg Tablet.

Can Lorbriqua 100mg Tablet cause high cholesterol or triglyceride levels?

Yes, Lorbriqua 100mg Tablet can significantly raise cholesterol and triglyceride levels in your blood. Doctors may prescribe lipid-lowering medicines to manage this. Regular blood tests will be needed to monitor your lipid profile during treatment.

Can Lorbriqua 100mg Tablet cause heart problems?

Yes, Lorbriqua 100mg Tablet can cause heart rhythm issues such as atrioventricular (AV) block or PR interval prolongation. Your doctor may perform ECG tests before and during Lorbriqua 100mg Tablet treatment, especially if you have a history of heart disease.

What are the warning signs of serious lung problems from Lorbriqua 100mg Tablet?

If you develop symptoms like shortness of breath, coughing, or fever, it may indicate lung inflammation (pneumonitis or ILD), which is a rare but serious side effect of Lorbriqua 100mg Tablet. Inform your doctor immediately if you experience any of these symptoms, as treatment may need to be stopped.

How long does it take for Lorbriqua 100mg Tablet to work?

The time it takes to see results varies from person to person. Some patients may notice improvement within a few weeks, while others may take longer. Your doctor will monitor your progress through regular check-ups and scans.

Can I stop taking Lorbriqua 100mg Tablet if I feel better?

No, do not stop taking Lorbriqua 100mg Tablet without consulting your doctor. Stopping the medication abruptly can cause the cancer to grow or spread. Always follow your doctor’s instructions.

Can Lorbriqua 100mg Tablet cure my cancer?

Lorbriqua 100mg Tablet is not a cure for cancer, but it can help control the growth and spread of ALK-positive non-small cell lung cancer. It may improve symptoms and prolong survival in some patients.

Will I need regular tests during Lorbriqua 100mg Tablet treatment?

Yes, your doctor will likely advise regular blood tests, scans, and check-ups to monitor your response to the treatment and check for any side effects.

Fact Box

Chemical Class

Macrolactams

Habit Forming

Therapeutic Class

ANTI NEOPLASTICS

Action Class

Tyrosine Kinase Inhibitors (TKIs)

References

Lorlatinib [Prescribing Information]. New York, NY: Pfizer Labs.; 2024. [Accessed 02 Jan. 2026]. Available from:
Lorlatinib. New York, NY: Pfizer Laboratories Div Pfizer Inc.; 2026

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Pfizer Ltd
Address: The Capital, 1802, 18th Floor , Plot No. C-70, ‘G’ Block , Bandra Kurla Complex, Bandra East , Mumbai – 400051.

Vendor Details

Country of origin: Germany
A licensed vendor partner from your nearest location will deliver Lorbriqua 100mg Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India

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Why we need a prescription?

Lorbriqua 100mg Tablet

Save more with additional offers

General Information

Contains

Marketer

Product introduction

Uses of Lorbriqua Tablet

Benefits of Lorbriqua Tablet

Side effects of Lorbriqua Tablet

How to use Lorbriqua Tablet

How Lorbriqua Tablet works

All substitutes for Lorbriqua 100mg Tablet

Lorbriqua 100mg Tablet

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Ethinyl Estradiol (Injection Route)

Phenytoin (Oral Route)

Phenytoin (Injection Route)

Pimozide (Oral Route)

Primidone (Oral Route)

Frequently asked questions

What is Lorbriqua 100mg Tablet used for?

Is Lorbriqua 100mg Tablet effective for lung cancer patients who have failed previous ALK therapies?

Can Lorbriqua 100mg Tablet cause serious mental or mood changes?

Is it safe to take Lorbriqua 100mg Tablet if I am pregnant or planning to become pregnant?

Can Lorbriqua 100mg Tablet cause high cholesterol or triglyceride levels?

Can Lorbriqua 100mg Tablet cause heart problems?

What are the warning signs of serious lung problems from Lorbriqua 100mg Tablet?

How long does it take for Lorbriqua 100mg Tablet to work?

Can I stop taking Lorbriqua 100mg Tablet if I feel better?

Can Lorbriqua 100mg Tablet cure my cancer?

Will I need regular tests during Lorbriqua 100mg Tablet treatment?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

In case of any issues, contact us

Lab tests offered by us

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