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Ornishel Granules is used in the treatment of liver disease. It protects the liver from harmful chemical substances and improves the functioning of the liver.

Written By Dr. Subita Alagh, BDS,
Reviewed By Dr. Mekhala Chandra, MD, MBBS,
Last updated on 08 May 2026 | 03:58 PM (IST)
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Ornishel Granules image

Product introduction

Ornishel Granules must be administered under the supervision of healthcare professionals. The course of the treatment should be completed for better results.


This medicine is well tolerated with little or no side effects. However, if you experience any symptoms which you think are due to the medicine, inform your doctor. If any kind of allergic reaction (severe rashes, difficulty in swallowing, shortness of breath, swelling, etc.) occurs, you must call for immediate medical help.


Inform your doctor before taking the medicine if you have any other medical conditions or are taking any other medications. Pregnant and breastfeeding women should take it only if advised by the doctor. While taking the medicine, your doctor may advise regular blood tests to monitor blood creatinine and blood/urine urea levels.

Uses of Ornishel Granules

  • Treatment of Liver disease

Benefits of Ornishel Granules

Treatment of Liver disease
Ornishel Granules protects the liver from damage against harmful chemicals known as free radicals, thereby improving overall health of the liver. This helps the liver to perform its normal functions. It is given as an injection by a doctor or nurse and should not be self-administered. To make the medicine more effective and for general health benefits, stop smoking, maintain a healthy weight, and do not drink too much alcohol.

Side effects of Ornishel Granules

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Ornishel
  • Injection site reactions (pain, swelling, redness)

How to use Ornishel Granules

Take this medicine in the dose and duration as advised by your doctor. Check the label for directions before use. Empty the granules in a glass of water/milk, stir it and consume immediately. Ornishel Granules may be taken with or without food.

How Ornishel Granules works

Ornishel Granules lowers blood ammonia levels by supporting the body’s natural detoxification pathways. Ornithine acts as a key substrate in the urea cycle in liver cells, helping convert toxic ammonia into urea for safe excretion. Aspartate supports the formation of glutamate, which then combines with ammonia to form glutamine in liver and muscle tissues. Through these urea and glutamine synthesis pathways, L-Ornithine L-Aspartate reduces ammonia accumulation and helps protect brain function in liver disease.

Quick tips

  • You will be regularly monitored for blood creatinine and blood/urine urea levels.
  • Inform your doctor if you are pregnant, planning a pregnancy, or breastfeeding.
  • Do not take this medicine if you are allergic to any of its ingredients.

Safety advice

Alcohol

Alcohol

CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Ornishel Granules. Please consult your doctor.
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
The safety of Ornishel Granules during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Information regarding the use of Ornishel Granules during breastfeeding is not available. Please consult your doctor.
Driving

Driving

UNSAFE
Ornishel Granules may cause side effects that could affect your ability to drive.
Kidney

Kidney

CAUTION
Ornishel Granules should be used with caution in patients with kidney disease. Dose adjustment may be needed.
Liver

Liver

CAUTION
Ornishel Granules should be used with caution in patients with severe liver disease. Dose adjustment may be needed.

Frequently asked questions

No, it is not recommended to take alcohol when on Ornishel Granules. It is a medicine given in cases of liver failure. Although, there are no reported interaction. Still, in cases of liver failure, alcohol should be avoided as it could worsen your complication of liver disease.
Ornishel Granules is made up of two amino acids. It is most commonly used in cases of liver diseases in order to prevent it from abnormal brain function called hepatic encephalopathy.
Ornishel Granules is not recommended for use in pregnant or breastfeeding women unless absolutely necessary. It is advised that if your doctor prescribes you this medicine then you must discuss all the risks and benefits associated with this medicine.
Hepatic encephalopathy (HE) is a brain disorder which occurs in patients with liver failure. In liver failure, there is increased bacterial growth in the intestine which leads to an accumulation of ammonia in blood. This deteriorating condition of the liver starts affecting the functioning of the brain, causing Hepatic encephalopathy. Ornishel Granules works by detoxifying the ammonia from the blood, hence decreasing the free ammonia from the body. This, as a result, helps decrease the abnormal functioning of the brain caused due to liver failure.
Ornishel Granules can be given orally, with or without food. Your doctor will suggest the appropriate dose depending on the patient’s health condition and severity of the disease.

Fact Box

Chemical Class

Amino acid derivative

Habit Forming

No

Therapeutic Class

GASTRO INTESTINAL

Action Class

Amino Acids
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Shelton Pharmaceuticals Pvt Ltd
Address: Unit No 49, M2k Corporate Park,Mayfield garden, N- Block, Sector 51, Gurugram, Haryana - 122004

Vendor Details

Country of origin: India
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