Samehep Tablet is a medicine used for the treatment of liver disease associated with reduced bile formation (intrahepatic cholestasis). It protects the liver cells from toxins and helps the liver to perform its normal functions.

Samehep Tablet may be taken with or without food. The dose will depend on the severity of your condition and your body weight. It is best swallowed whole, but you may need to break them to get the correct dose. This medicine needs to be taken regularly to get the most benefit and you may have to take it for several months or longer, so try to get into a routine. Keep using it as prescribed even if your symptoms disappear.

Use of this medicine may cause some common side effects such as headache, dizziness, vomiting, upset stomach, diarrhea, constipation, and insomnia. Not everyone gets side effects. If you are worried about them, or they do not go away, let your doctor know. If you have problems with diarrhea your doctor may reduce the dose or stop the treatment. Drink enough water or fluids to stay hydrated in case of severe diarrhea and constipation.

Before taking this medicine, you should tell your doctor if you are pregnant, planning pregnancy, or breastfeeding. Using this medicine can reduce or increase the effect of some other medicines so tell your doctor, all other medicines you are taking. Avoid drinking alcohol as it might increase side effects.

Uses of Samehep Tablet

Treatment of Liver disease

Side effects of Samehep Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Samehep

Headache
Dizziness
Vomiting
Upset stomach
Diarrhea
Constipation
Insomnia (difficulty in sleeping)

How to use Samehep Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Samehep Tablet may be taken with or without food, but it is better to take it at a fixed time.

How Samehep Tablet works

Samehep Tablet contains S-Adenosyl L-Methoinine Disulfate Tosylate, also known as SAMe, a nutritional supplement, that can restore Glutathione concentrations in the liver and also improves liver damage. SAMe is also involved in many biochemical reactions in the human body that regulate the growth, death and differentiation of hepatocytes (liver cells). Because liver function is compromised in people suffering from liver disease, supplementation with Samehep Tablet is beneficial.

Safety advice

Alcohol

UNSAFE

It is unsafe to consume alcohol with Samehep Tablet.

Pregnancy

CONSULT YOUR DOCTOR

Samehep Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Breast feeding

CONSULT YOUR DOCTOR

Information regarding the use of Samehep Tablet during breastfeeding is not available. Please consult your doctor.

Driving

UNSAFE

Samehep Tablet may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Kidney

CONSULT YOUR DOCTOR

There is limited information available on the use of Samehep Tablet in patients with kidney disease. Please consult your doctor.

Liver

SAFE IF PRESCRIBED

Samehep Tablet is safe to use in patients with liver disease. No dose adjustment of Samehep Tablet is recommended.

What if you forget to take Samehep Tablet?

If you miss a dose of Samehep Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.

Samehep Tablet

₹47.9/Tablet

Livopam 400 Tablet

Pamasha Pharmaceuticals Private Limited

₹55.1/tablet

15% costlier

Asmymax 400mg Tablet

Radicool Pharmaceutical Pvt Ltd

₹67.7/tablet

41% costlier

S Deno 400mg Tablet

Winsome Bioceuticals

₹58.7/tablet

23% costlier

Mednosam 400 Tablet

Medvik Pharmaceuticals Pvt Ltd

₹77.6/tablet

62% costlier

Samydep 400mg Tablet

Amytree Pharmaceuticals

₹57.9/tablet

21% costlier

View all substitutes

Quick tips

Samehep Tablet is prescribed for the treatment of liver disease.
Seek immediate medical attention if you have difficulty breathing after taking the drug.
Samehep Tablet may interfere with surgery. Its use should be discontinued at least two weeks prior to surgery.
Avoid smoking and drinking as it further degrades liver functioning.
You will be regularly monitored for blood creatinine and blood/urine urea levels while on treatment with Samehep Tablet.

Fact Box

Chemical Class

5'-deoxy-5'-thionucleosides

Habit Forming

Therapeutic Class

GASTRO INTESTINAL

Action Class

Hepatoprotectives

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Disclaimer:

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

Guo T, Chang L, Xiao Y, et al. S-adenosyl-L-methionine for the treatment of chronic liver disease: A systematic review and meta-analysis. PLoS One. 2015;10(3):e0122124. [Accessed 02 Jul. 2021] (online) Available from:
Noureddin M, Sander-Struckmeier S, Mato JM. Early treatment efficacy of S-adenosylmethionine in patients with intrahepatic cholestasis: A systematic review. World J Hepatol. 2020;12(2):46-63. [Accessed 02 Jul. 2021] (online) Available from:
La Renon: S-Adenosyl-L-methionine (SAMe) [Product Information]. [Accessed 25 Jul. 2024] (online) Available from:

Marketer details

Name: Jupiter Formulations Private Limited

Address: Crystal Plaza,Opposite Inorbit Mall,Andheri West Mumbai,Maharashtra.

Country of origin: India

The list of available options shown with the same composition has been prepared upon the advice of registered medical practitioners, pharmacists affiliated with TATA 1MG. TATA 1MG does not promote any pharmaceutical product of any particular company, and all recommendations are based on the medical opinion, advisories from specialist medical and pharmaceutical professionals.