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Treoall Injection

Prescription Required
SALT COMPOSITION
Salt Synonyms
Dihydroxybusulfan
Storage
Store below 25°C

Product introduction

Treoall Injection is used in the treatment of blood cancer. It is used in combination with another cancer medicine called fludarabine in adults and children as young as one month of age with blood cancers as well as in adults requiring a bone marrow transplant.

Treoall Injection is given as an injection into veins by the healthcare provider. This will depend on what you are being treated for and may change from time to time. It may take several weeks or months for you to see or feel the benefits. The dose and duration of treatment will be decided by your doctor.

The most common side effects of this medicine include infections, weakness, bleeding, difficulty in breathing, nausea, hair loss, and discoloration of the skin. If these bother you or appear serious, let your doctor know. There may be ways of reducing or preventing them.

Inform your doctor if you have a medical history of bleeding disorders, heart or liver disease, radiation treatment or any infection. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using.  Inform your doctor immediately if you notice unusual bruising or bleeding or if you have dark, tarry, or bloody stools and sore throat.

This medicine is known to reduce the number of blood cells in your blood thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells along with kidney, liver and heart function during treatment with this medicine. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.

Uses of Treoall Injection

Benefits of Treoall Injection

In Blood cancer

Blood cancer, also called leukemia, is a cancer of the blood-forming tissues that decreases the body's ability to fight infection. It is used as a 'conditioning' treatment to get rid of the bone marrow and make room for the transplanted bone marrow cells, which can then produce healthy blood cells. It is given with another cancer medicine called fludarabine in adults and children requiring a bone marrow transplant. You should avoid drinking alcohol while having this treatment and drink plenty of water to stay hydrated.

Side effects of Treoall Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Treoall

  • Infection
  • Weakness
  • Bleeding
  • Breathing problems
  • Nausea
  • Hair loss
  • Skin discoloration

How to use Treoall Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Treoall Injection works

Treoall Injection is an alkylating agent. It works by forming cross-links between DNA strands preventing cell replication and leading to the death of the cell.

Safety advice

Alcohol
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Treoall Injection. Please consult your doctor.
Pregnancy
CONSULT YOUR DOCTOR
Treoall Injection is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
Breast feeding
CONSULT YOUR DOCTOR
Information regarding the use of Treoall Injection during breastfeeding is not available. Please consult your doctor.
Driving
UNSAFE
Treoall Injection may cause side effects which could affect your ability to drive.
Do not drive if you experience nausea or vomiting.
Kidney
CAUTION
Treoall Injection should be used with caution in patients with severe kidney disease. Dose adjustment of Treoall Injection may be needed. Please consult your doctor.
Liver
CAUTION
Treoall Injection should be used with caution in patients with severe liver disease. Dose adjustment of Treoall Injection may be needed. Please consult your doctor.

What if you forget to take Treoall Injection?

If you miss a dose of Treoall Injection, consult your doctor.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.
Treoall Injection
₹21329/Injection
Emtreo Injection
Emcure Pharmaceuticals Ltd
₹21500/injection
2% cheaper

Quick tips

  • Inform your doctor if you develop shortness of breath during the treatment with Treoall Injection.
  • Use contraceptives, and do not conceive a child (get pregnant) while taking this medicine. Barrier methods of contraception, such as condoms, should be used during therapy and six months after treatment.
  • You may be at risk of infection, so try to avoid crowds or people with colds, and immediately report fever or any other signs of infection to your health care provider.
  • Avoid activities that may cause injury and bleeding during your treatment.
  • Do not receive any kind of immunization or vaccination (especially live vaccines) without your doctor’s approval while taking Treoall Injection.
  • To reduce nausea, take anti-nausea medications as prescribed by your doctor, and eat small, frequent meals.
  • Drink more fluids than usual for up to 24 hours after your treatment unless instructed otherwise.
  • Swelling of the gums may occur as a side effect. Frequent mouth rinses, good oral hygiene, and the application of ice may give relief.
  • Inform your doctor if you develop shortness of breath during the treatment with Treoall Injection.
  • Use contraceptives, and do not conceive a child (get pregnant) while taking this medicine. Barrier methods of contraception, such as condoms, should be used during therapy and six months after treatment.
  • You may be at risk of infection, so try to avoid crowds or people with colds, and immediately report fever or any other signs of infection to your health care provider.
  • Avoid activities that may cause injury and bleeding during your treatment.
  • Do not receive any kind of immunization or vaccination (especially live vaccines) without your doctor’s approval while taking Treoall Injection.
  • To reduce nausea, take anti-nausea medications as prescribed by your doctor, and eat small, frequent meals.
  • Drink more fluids than usual for up to 24 hours after your treatment unless instructed otherwise.
  • Swelling of the gums may occur as a side effect. Frequent mouth rinses, good oral hygiene, and the application of ice may give relief.

Fact Box

Chemical Class
Organosulfonic acid esters
Habit Forming
No
Action Class
Alkylating agent

FAQs

Should I avoid any food and drinks while taking Treoall Injection?

You can continue with your normal diet unless your doctor tells you otherwise. However, it is advisable to sip water regularly to prevent dehydration, eat small, simple but nourishing snacks every few hours rather than large meals, and suck on hard candy or popsicles to prevent nausea and vomiting.

Why am I experiencing bleeding from my gums after brushing my teeth?

You may experience bleeding from gums due to a drop in the number of platelets (blood cells) in your blood. These blood cells help the blood clot when we bruise ourselves.

How to cope with tiredness and weakness after starting the treatment with Treoall Injection?

Various things can help you reduce tiredness and cope with it, for example, gentle exercise. However, always consult your doctor before doing any kind of exercise.

Does Treoall Injection cause hair loss?

Yes, while taking this medicine, your hair may become brittle and break. You may also experience patchy hair loss or thinning. These conditions tend to resolve once the treatment is stopped. Be gentle when brushing and washing hair to manage hair loss.

I have noticed some changes in my skin after taking Treoall Injection? What should I do?

Use a moisturizer to get relief from rashes, and dry and itchy skin. Avoid direct sunlight, wear protective clothing, and use sunscreen (SPF of more than 15) whenever you step outdoors. Do not go swimming if you have a rash because the chlorine in the water can worsen it. Avoid hot water baths and wear loose and cotton fabric clothes. Your skin will tend to become better once the treatment is stopped.

What should I avoid during my treatment with Treoall Injection?

During your treatment, it is advisable to avoid caffeine as it can make you feel dehydrated, avoid fatty fried, spicy, and overly sweet foods, as they may induce nausea, and avoid alcohol and smoking. It is also advisable to avoid crowds or people with colds, as you may be at risk of infection as well as sun exposure to prevent rashes and dry skin. Use caution with sharp objects like razors or nail cutters and avoid activities such as contact sports to lower the chance of getting cut, bruised, or injured.

Can Treoall Injection be taken during pregnancy?

This treatment may harm a baby developing in the womb. Therefore, it is important not to conceive or father a child while you are on a treatment with Treoall Injection and for at least 6 months after stopping the treatment. Talk to your doctor about effective contraception before starting the treatment.

What are some of the tests conducted before and during the treatment with Treoall Injection?

Your doctor will prescribe blood tests to check your levels of blood cells and how well your liver and kidneys are working.

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Disclaimer:

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

  1. Treosulfan [Summary of Product Characteristics]. Wedel,Germany: medac Gesellschaft für klinische Spezialpräparate mbH; 2019. [Accessed 25th Nov. 2022] (online) Available from:External Link
  2. Treosulfan [Package Leaflet]. Luton, UK: Emcure Pharma UK Ltd.; 2021. [Accessed 25th Nov. 2022] (online) Available from:External Link

Marketer details

Name: Hetero Healthcare Limited
Address: S.no: 80-84, Melange towers, PatrikaNagar,Madhapur,Hyderabad. Telangana-500081.
Country of origin: India
Expires on or after: February, 2025

A licensed vendor partner from your nearest location will deliver Treoall Injection. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India

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1.0 Injection in 1 vial
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