AMA-M2
Understanding AMA-M2
What is AMA-M2?
AMA-M2 test helps to detect primary biliary cholangitis (PBC) by detecting AMA-M2 (IgG) antibodies. The antimitochondrial M2 (AMA-M2) antibodies attack liver cells leading to liver damage. PBC is more common in women compared to men. This test detects the presence of M2 antibodies against liver cells. You may get this test done if you have symptoms like fatigue, belly pain, weight loss, poor appetite, dry eyes or mouth, jaundice, and swelling in the belly or ankles. To reduce the complications of PBC, take the prescribed medicines on time, eat a healthy diet, and exercise regularly.
What does AMA-M2 measure?
The AMA-M2 test detects the presence of anti-mitochondrial antibodies (AMAs) that play a critical role in the context of primary biliary cholangitis (PBC), a chronic liver disease. These autoantibodies target specific proteins in the mitochondria and are found in approximately 95% of individuals suffering from PBC, making them highly specific for the disease. A positive AMA-M2 test result suggests that the body is producing antibodies against these mitochondrial proteins, which can help confirm a PBC diagnosis. On the other hand, a negative result generally indicates that PBC is unlikely, although it doesn't completely rule out other liver conditions.
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