Haptoglobin

A haptoglobin test measures the amount of haptoglobin present in your blood. Haptoglobin is a protein produced by your liver. It binds with hemoglobin, which is a protein found in red blood cells.

 The haptoglobin test may be done if you have symptoms and signs of anemia, such as paleness, tiredness, and weakness, along with findings suggestive of hemolytic anemia, such as jaundice and dark urine. Hemolytic anemia is a disorder that happens when your red blood cells are destroyed faster than they can be replaced.

You may also need this test if you've had a blood transfusion and to assess the functional state of the liver

As haptoglobin is an acute-phase protein, this test can be used in diagnosing the development of any inflammatory process (infection, injury, allergy, etc.) which may increase the levels of plasma haptoglobin,

A decrease in haptoglobin level supports the presence of hemolytic anemia due to different causes such as certain drugs & medications, infections, G6PD deficiency, abnormal hemoglobins like sickle cell anemia & thalassemia, artificial heart valves, etc., Hemolytic transfusion reaction, Thermal burns, Autoimmune hemolytic anemia

An increase in Haptoglobin can be seen in  acute inflammation, protein-losing enteropathy, protein-losing nephropathy, tissue

necrosis, stress, etc.