Tissue Transglutaminase Antibody, IgA

Also known as IgA anti-tissue transglutaminase, IgA Anti-tTG, Celiac disease testing, Celiac disease antibody testing

₹979~~₹1100~~ 11% Off

You need to provide

Blood

This test is for

Male, Female

Test Preparation

No special preparation is required.

Understanding Tissue Transglutaminase Antibody, IgA

What is Tissue Transglutaminase Antibody, IgA?

A Tissue Transglutaminase Antibody, IgA test helps to identify the presence of specific antibodies in the blood associated with celiac disease, an autoimmune disorder triggered by the ingestion of gluten-containing foods. It helps assess the immune response to gluten, helping in the assessment and management of celiac disease.

Tissue transglutaminase (tTG) is an enzyme that plays an important role in various biological processes. One of its key functions is to help in the formation of stable protein structures by catalyzing the binding of proteins. tTG enzyme is implicated in the immune response triggered by gluten (a protein found in cereals like wheat, barley, and rye and foods like cakes, bread, and pasta) consumption.

In individuals with celiac disease, exposure to gluten often prompts an abnormal immune response where antibodies, including anti-tissue transglutaminase antibodies, are produced. These antibodies target the tTG enzyme, causing characteristic damage to the lining of the small intestine. Untreated celiac disease can lead to potential complications like malabsorption, malnutrition, weakened bones (osteoporosis), fertility problems, or an increased risk of intestinal cancer. It may also increase the risk of developing other autoimmune conditions like rheumatoid arthritis.

A Tissue Transglutaminase Antibody, IgA test helps in the diagnosis and timely management of celiac disease in individuals experiencing digestive problems, unexplained symptoms such as chronic diarrhea, bloating, stomach pain, etc. suggestive of celiac disease, or those with a family history of celiac disease or having risk factors such as diabetes, thyroid problems etc.

No special preparation is required before undertaking a Tissue Transglutaminase Antibody, IgA test. However, to diagnose celiac disease, the test should be performed before eliminating gluten from the diet.

Lab test results may vary across different laboratories. Abnormal test results require an expert interpretation, therefore, never try to self-medicate at home based solely on these results, and always consult a doctor for proper understanding of the test results. The insights from a Tissue Transglutaminase Antibody, IgA test are valuable in the pursuit of an accurate diagnosis and effective management of celiac disease.

What is Tissue Transglutaminase Antibody, IgA used for?

A Tissue Transglutaminase Antibody, IgA test is done:

To diagnose celiac disease by detecting antibodies related to gluten sensitivity.
To confirm if symptoms like digestive problems, fatigue, or skin problems are due to celiac disease.
As a part of screening for individuals with a family history of celiac disease or those experiencing unexplained symptoms.
To assess gluten sensitivity beyond celiac disease.
To guide dietary choices for individuals with gluten-related problems.
To monitor the treatment response in patients with celiac disease.
To monitor the effectiveness of a gluten-free diet in individuals with celiac disease.
As a part of the diagnostic process for autoimmune disorders associated with gluten sensitivity.

What does Tissue Transglutaminase Antibody, IgA measure?

A Tissue Transglutaminase Antibody, IgA test measures the presence of specific antibodies in the blood. These antibodies, specifically immunoglobulin A (IgA) antibodies, are produced in response to the tissue transglutaminase(tTG) enzyme which is involved in the body’s reaction to gluten.

Elevated levels of tTG IgA antibodies in the blood indicate an immune response to gluten, helping doctors confirm the presence of celiac disease or assess gluten sensitivity. A Tissue Transglutaminase Antibody, IgA test provides important information for the diagnosis and management of conditions associated with gluten-related disorders.

Interpreting Tissue Transglutaminase Antibody, IgA results

Interpretations

Result (In Units)	Interpretation
<20	Negative
20-30	Weak Positive
>30	Positive

Reference range may vary from lab to lab*

A positive anti-tissue transglutaminase antibody IgA test usually indicates celiac disease
A negative test usually means that symptoms are not likely due to celiac disease. If the person being tested has not consumed any gluten for several weeks or months prior to the test, then the test may show false-negative results
All antibody tests for celiac disease are usually followed by an intestinal biopsy which is the gold standard for diagnosis of this condition

Answers to Patient Concerns & Frequently Asked Questions (FAQs) about Tissue Transglutaminase Antibody, IgA

Frequently Asked Questions about Tissue Transglutaminase Antibody, IgA

Q. When should I consider getting a Tissue Transglutaminase Antibody, IgA test?

You should consider a Tissue Transglutaminase Antibody, IgA test if you are experiencing symptoms suggestive of celiac disease. It is also useful for assessing the effectiveness of a gluten-free diet.

Q. Is there any risk associated with a Tissue Transglutaminase Antibody, IgA test?

No, a Tissue Transglutaminase Antibody, IgA test is generally a safe procedure. While rare, bruising, bleeding, and infection at the puncture site may occur. In very uncommon cases, there can be swelling of the vein after the blood withdrawal.

Q. Is a Tissue Transglutaminase Antibody, IgA test safe for children?

Yes, a Tissue Transglutaminase Antibody, IgA test is considered safe for children.

Q. What is the best way to treat celiac disease?

The most effective treatment for celiac disease is to follow a strict gluten-free diet for life.

Q. What foods are gluten-free?

Gluten-free foods include fruits and vegetables, beans, seeds, legumes, nuts, fish and poultry products, and low-fat dairy products such as cheese, butter, rice, soy, corn, and potatoes.