Acabrunat Capsule is used in the treatment of blood cancer. It is given to patients aged more than 18 years who have received at least one prior treatment for their cancer. It is unknown if this drug is safe and effective in children.

Acabrunat Capsule is taken orally, preferably with food or between meals. It should be used in the dose and duration prescribed by your doctor. It is advised to take this medicine at a fixed time and for as long as the doctor prescribes to avoid missing a dose. It may take several weeks or months for you to see or feel the benefits.

The most common side effects of Acabrunat Capsule include anemia, neutropenia, upper respiratory tract infection, thrombocytopenia, headache, diarrhea, and musculoskeletal pain. If these bother you or appear serious, let your doctor know as they might suggest ways of reducing or preventing these side effects.

Inform your doctor if you have a medical history of bleeding disorders, heart or liver disease, radiation treatment, or any infection. The risk of bleeding may increase if the patient is taking a blood thinner medicine along with Acabrunat Capsule. Many other medicines can affect or be affected by this medicine, so let your doctor know of all the medications you are using. Inform the doctor immediately if unusual bruising or bleeding or dark, tarry, or bloody stools and sore throat are noticed.

This medicine is known to reduce the number of blood cells in your blood, thereby increasing the susceptibility to infections. Regular blood tests are required to check the blood cell count along with the kidneys, liver, and heart functions during the treatment with this medicine. The use of effective contraception by both males and females during the treatment is important to avoid pregnancy.

Uses of Acabrunat Capsule

Treatment of Blood cancer

Benefits of Acabrunat Capsule

In Treatment of Blood cancer

Blood cancer, also called leukemia, is a cancer of the blood-forming tissues that decreases the body's ability to fight infection. Acabrunat Capsule kills or stops the growth and prevents the multiplication of cancer cells. It is a potent and very toxic medicine, and one should discuss the risks and benefits with the doctor before taking this drug. Avoid drinking alcohol while taking this medicine and also inform the doctor if you have any persistent side effects.

Side effects of Acabrunat Capsule

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Acabrunat

Anemia (low number of red blood cells)
Decreased white blood cell count (neutrophils)
Upper respiratory tract infection
Low blood platelets
Headache
Diarrhea
Musculoskeletal (bone, muscle or joint) pain

How to use Acabrunat Capsule

Take this medicine in the dose and duration as advised by your doctor. Acabrunat Capsule may be taken with or without food, but it is better to take it at a fixed time.

How Acabrunat Capsule works

Acabrunat Capsule works by blocking the action of an abnormal protein that promotes the multiplication of cancer cells. This helps stop the spread of cancer cells.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Acabrunat Capsule. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

Acabrunat Capsule may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Breast feeding

CONSULT YOUR DOCTOR

Acabrunat Capsule is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

Driving

SAFE

Acabrunat Capsule does not usually affect your ability to drive.

Kidney

SAFE IF PRESCRIBED

Acabrunat Capsule is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Acabrunat Capsule may not be needed in these patients. Please consult your doctor.

Liver

SAFE IF PRESCRIBED

Acabrunat Capsule is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Acabrunat Capsule may not be needed in these patients. Please consult your doctor.

What if you forget to take Acabrunat Capsule?

If you miss a dose of Acabrunat Capsule, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.

Acabrunat Capsule

₹500.9/Capsule

Acaone 100mg Capsule

MSN Laboratories

₹440.68/capsule

12% cheaper

Betatinib Capsule

Adley Formulations

₹252.17/capsule

50% cheaper

Acalnib 100mg Capsule

Hetero Healthcare Limited

₹410.47/capsule

18% cheaper

Acaya Capsule

Zydus Healthcare Limited

₹454.6/capsule

9% cheaper

Acaone 100mg Capsule

MSN Laboratories

₹491.93/capsule

2% cheaper

Quick tips

Before taking Acabrunat Capsule, tell your doctor about other medications (including prescription, over-the-counter, vitamins, herbal remedies, etc.).
Avoid the use of antacids within 2 hours of taking this medicine.
You may be at risk of infection, so try to avoid crowds or people with colds, and immediately report fever or any other signs of infection to your doctor.
Avoid sun exposure. Wear SPF 15 (or higher) sunblock and protective clothing.
Drink plenty of water every 24 hours after the start of the treatment.
Eat foods that may help reduce diarrhea and take adequate rest.
Avoid contact sports or other situations where you may bruise or get injured since this medicine increases the risk of bleeding. Also, tell your doctor about any planned surgeries or dental procedures while taking Acabrunat Capsule.
Before taking Acabrunat Capsule, tell your doctor about other medications (including prescription, over-the-counter, vitamins, herbal remedies, etc.).
Avoid the use of antacids within 2 hours of taking this medicine.
You may be at risk of infection, so try to avoid crowds or people with colds, and immediately report fever or any other signs of infection to your doctor.
Avoid sun exposure. Wear SPF 15 (or higher) sunblock and protective clothing.
Drink plenty of water every 24 hours after the start of the treatment.
Eat foods that may help reduce diarrhea and take adequate rest.
Avoid contact sports or other situations where you may bruise or get injured since this medicine increases the risk of bleeding. Also, tell your doctor about any planned surgeries or dental procedures while taking Acabrunat Capsule.

Fact Box

Chemical Class

Phenylimidazoles

Habit Forming

Therapeutic Class

ANTI NEOPLASTICS

Action Class

Tyrosine kinase inhibitors

Interaction with drugs

Taking Acabrunat with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Fluconazole (Oral Route) Moderate

Fluconazole may raise blood levels of Acalabrutinib. watch out for symptoms of Acalabrutinib side effects such as headache, fatigue, nausea, drowsiness, weight gain, acne or muscl... More

Eicosapentaenoic Acid (Oral Route) Moderate

Concurrent use may increase the risk of bleeding. Inform your doctor if you notice any signs of bleeding (bruising, bleeding gums, blood in stool/vomit/urine).

Rifampicin (Oral Route) Moderate

Rifampicin may reduce blood levels of Acalabrutinib. Do not consume Acalabrutinib with Rifampicin. If concurrent use is essential, your doctor may monitor your treatment and adjus... More

Rifampicin (Injection Route) Moderate

Rifampicin may reduce blood levels of Acalabrutinib. Do not consume Acalabrutinib with Rifampicin. If concurrent use is essential, your doctor may monitor your treatment and adjus... More

Mifepristone (Oral Route) Moderate

Mifepristone may raise blood levels of Acalabrutinib. Do not consume Mifepristone with Acalabrutinib. If concurrent use is essential, watch out for symptoms such as weight gain, d... More

View all drug interactions

Patient concerns

Can blood cancer patients 1st stage do sex with normal girl Sir a blood cancer patients do sex with normal girl can any problem or cause doing with girl or side effect give suggestions Thanks

Dr. Vijay Sharnangat

Medical Oncology and Hematology

Wait till blood cancer gets cured.

Blood Cancer. Is there any medicine to cure blood cancer.

Dr. Aanchal Maheshwari

Ayurveda

Case has to be seen in person

FAQs

I am experiencing nausea and extreme tiredness. Is this due to Acabrunat Capsule?

Nausea and fatigue or tiredness are some of the common side effects of Acabrunat Capsule. Eat smaller, more frequent meals to reduce the feeling of nausea. Avoid salty, spicy, fried, or fatty food items. Take plenty of rest and do light exercise daily to keep yourself active and reduce fatigue.

How to get relief from diarrhea while on treatment with Acabrunat Capsule?

Food items with soluble fiber can help relieve diarrhea as they help absorb excess fluid from the body. These food items include bananas (ripe), oranges, boiled potatoes, white rice, curd, and oatmeal. Diarrhea can cause dehydration in the body, so drink 8-10 glasses of water to avoid dehydration. You can also have soup and juice frequently to hydrate yourself.

Should I avoid any food and drinks while taking Acabrunat Capsule?

You can continue with your normal diet unless your doctor tells you otherwise. However, it is advisable to sip water regularly to prevent dehydration, eat small, simple but nourishing snacks every few hours rather than large meals, and suck on hard candy or popsicles to prevent nausea and vomiting.

I have noticed some changes in my skin after taking Acabrunat Capsule? What should I do?

Use a moisturizer to get relief from rashes and dry and itchy skin. Avoid direct sunlight, wear protective clothing, and use sunscreen (SPF of more than 15) whenever you step outdoors. Do not go swimming if you have a rash because the chlorine in the water can make it worse. Avoid hot water baths and wear loose and cotton fabric clothes. Your skin will tend to become better once treatment is stopped.

Why am I experiencing bleeding from my gums after brushing my teeth?

You may experience bleeding from gums due to a drop in the number of platelets (blood cells) in your blood. These blood cells help the blood clot when we bruise ourselves.

How to cope with tiredness and weakness after starting the treatment with Acabrunat Capsule?

Various things can help you to reduce tiredness and cope with it, for example, gentle exercise. However, always consult your doctor before doing any kind of exercise. Q. Can Acabrunat Capsule be taken with obinutuzumab?

What are some of the tests conducted before and during the treatment with Acabrunat Capsule?

Your doctor will prescribe blood tests to check your levels of blood cells and how well your liver and kidneys are working.

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Related lab tests

Complete Blood Count

Peripheral Smear Examination

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

1. Acalabrutinib [Prescribing Information]. Wilmington, DE: AstraZeneca Pharmaceuticals LP; 2022. [Accessed 16 Nov. 2022] (online) Available from:
2. Acalabrutinib [Summary of Product Characteristics]. Södertälje, Sweden: AstraZeneca AB; 2020. [Accessed 16 Nov. 2022] (online) Available from:
3. Acalabrutinib [EMC SmPC]. London, UK: AstraZeneca UK Limited; 2021. [Accessed 16 Nov. 2022] (online) Available from:

Marketer details

Name: Natco Pharma Ltd

Address: Natco House, Road No.2, Banjara Hills, Hyderabad-500 034, India

Country of origin: India

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