Ambristar 5mg Tablet

Reviewed By Dr. Rajeev Sharma, MBA, MBBS

Last updated on 31 Mar 2026 | 02:32 PM (IST)

Ambristar 5mg Tablet is a prescription medicine used to treat pulmonary arterial hypertension (high pressure in the blood vessels that carry blood from the heart to the lungs). It can even help improve your quality of life, exercise ability, and delay disease progression.

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General Information

Contains

Ambrisentan (5mg)

Marketer

Steris Healthcare Pvt Ltd

Storage

Store below 30°C

The content is shown in English

Product introduction

Ambristar 5mg Tablet may be taken with or without food. Take it in the dose and duration advised by your doctor. In case you missed a dose, take another one as soon as you remember it. Take it for as long as it is prescribed and do not stop taking the medicine on your own.

The most common side effects of this medicine are peripheral edema, nasal congestion, sinusitis, and flushing. Let your doctor know if any of these side effects bother you or persist for a longer duration. Dizziness may also occur in some people, so do not drive or do anything that requires mental focus if you experience such a symptom.

Before receiving the treatment, inform your doctor if you are on any medication for any other health condition. It should be used with caution in patients with liver or kidney disease. Attend regular follow-ups as advised by the doctor.

Uses of Ambristar Tablet

Treatment of Pulmonary arterial hypertension (PAH)

Benefits of Ambristar Tablet

Treatment of Pulmonary arterial hypertension (PAH)
Pulmonary arterial hypertension (PAH) is a condition in which the blood pressure in the arteries of the lungs becomes abnormally high, causing the heart to work harder and leading to symptoms such as breathlessness, fatigue, and chest pain. Ambristar 5mg Tablet is used to treat PAH by helping relax and widen the blood vessels in the lungs. This improves blood flow, lowers lung pressure, and makes it easier to perform daily activities with reduced symptoms, ultimately enhancing exercise capacity and quality of life.

Side effects of Ambristar Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Ambristar

Peripheral edema
Nasal congestion (stuffy nose)
Sinus inflammation
Flushing (sense of warmth in the face, ears, neck and trunk)

How to use Ambristar Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Ambristar 5mg Tablet may be taken with or without food.

How Ambristar Tablet works

Ambristar 5mg Tablet is an endothelin receptor blocker. It blocks the action of endothelin (a natural substance) that causes blood vessels to narrow (constrict). This narrowing increases the pressure in the blood vessels of the lungs. Ambristar 5mg Tablet helps relax these blood vessels and increases the supply of blood to the lungs.

All substitutes for Ambristar 5mg Tablet

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

Ambristar 5mg Tablet helps improve your quality of life, exercise ability, and delay disease progression.
Your doctor may ask you to get routine blood tests done to check for anemia and to assess the functioning of your liver.
Do not drive or do anything requiring concentration until you know how Ambristar 5mg Tablet affects you.
Notify your doctor if you are pregnant or planning to conceive or breastfeeding.
Females with reproductive potential should use a reliable form of birth control while using and 1 month after stopping Ambristar 5mg Tablet as it is toxic to an unborn baby.
Inform your doctor if you notice weight gain, swelling of your arms and legs, or difficulty breathing.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Ambristar 5mg Tablet. Please consult your doctor.

Pregnancy

UNSAFE

Ambristar 5mg Tablet is highly unsafe during pregnancy. It can cause serious harm to the unborn baby, including birth defects and pregnancy loss. Do not use this medicine if you are pregnant or planning to become pregnant.

Breast feeding

CONSULT YOUR DOCTOR

Information regarding the use of Ambristar 5mg Tablet during breastfeeding is not available. Please consult your doctor.

Driving

CAUTION

Ambristar 5mg Tablet may cause dizziness or weakness due to changes in blood pressure. Do not drive if these symptoms occur.

Kidney

CAUTION

Ambristar 5mg Tablet should be used with caution in patients with severe kidney disease. Dose adjustment may be needed.
Limited information is available on use of Ambristar 5mg Tablet in these patients. No dose adjustment is recommended in patients with mild to moderate kidney disease.

Liver

UNSAFE

Ambristar 5mg Tablet is unsafe to use in patients with liver disease and should be avoided.

Interaction with drugs

Taking Ambristar with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Moderate

Rifampicin (Oral Route)

Your doctor may monitor your treatment. Rifampicin may raise blood levels of Ambrisentan.

Moderate

Rifampicin (Injection Route)

Your doctor may monitor your treatment. Rifampicin may raise blood levels of Ambrisentan.

Moderate

Ciclosporin (Oral Route)

Watch out for symptoms such as constipation, flushing or swelling under the skin and consult your doctor if you experience them. Ciclosporin may raise blood levels of Ambrisentan.

Moderate

Ciclosporin (Injection Route)

Watch out for symptoms such as constipation, flushing or swelling under the skin and consult your doctor if you experience them. Ciclosporin may raise blood levels of Ambrisentan.

Mild

Conjugated Estrogens (Vaginal Route)

Talk to your doctor if you notice any unusual symptoms. Ambrisentan may raise blood levels of Conjugated Estrogens.

Frequently asked questions

Can Ambristar 5mg Tablet cause liver problems?

Yes, Ambristar 5mg Tablet commonly causes an increase in liver enzymes. It may rarely cause liver injury and inflammation of the liver because of the body’s own defences (autoimmune hepatitis). Consult your doctor if you have nausea, vomiting, loss of appetite, dark-colored urine and yellowing of the skin.

How should Ambristar 5mg Tablet be taken?

Usually, the doctors advise to take one dose of Ambristar 5mg Tablet. You can take it with or without food but prefer taking it at the same time each day. Swallow it whole with a glass of water. Do not crush, chew or break it into pieces.

Can I stop taking Ambristar 5mg Tablet on my own?

No, you should not stop taking Ambristar 5mg Tablet without consulting your doctor as this may worsen your condition. Talk to your doctor if you need to stop it.

What is the most important thing that I should know about Ambristar 5mg Tablet?

Ambristar 5mg Tablet may cause serious birth defects if taken during pregnancy. Therefore, every woman who is capable of becoming pregnant should get a pregnancy test done before starting Ambristar 5mg Tablet. Additionally, during treatment with Ambristar 5mg Tablet you should use two reliable methods of contraception to ensure that you do not get pregnant.

What are the serious side effects of Ambristar 5mg Tablet?

The serious side effects of Ambristar 5mg Tablet are swelling all over the body (fluid retention), decreased sperm count and low red blood cell count (anemia). Tell your doctor if you have any unusual weight gain, tiredness, or trouble breathing.

Why have I been prescribed Ambristar 5mg Tablet?

Ambristar 5mg Tablet is used to treat pulmonary hypertension in adults. Pulmonary hypertension is a condition wherein there is increased blood pressure in the pulmonary arteries (blood vessels that carry blood from heart to lungs). Ambristar 5mg Tablet lowers the blood pressure by relaxing the pulmonary arteries, making it easier for the heart to pump blood through them.

What are the symptoms of overdose of Ambristar 5mg Tablet?

Taking more than the recommended dose of Ambristar 5mg Tablet may cause headache, flushing, dizziness, or nausea. It may cause low blood pressure which may further lead to lightheadedness. Contact your doctor immediately or seek emergency medical services in a nearby hospital if you take more than the recommended doses of this medicine.

Fact Box

Chemical Class

Diphenylmethanes

Habit Forming

Therapeutic Class

CARDIAC

Action Class

Endothelin Receptor Antagonists (ERAs)

References

Barnes PJ. Pulmonary Pharmacology. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 1059.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 39-50.
Ambrisentan [EMC SmPC]. London, UK: GlaxoSmithKline UK; 2025. [Accessed 06 Nov. 2025] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 01 Apr. 2019] (online) Available from:
Ambrisentan [Patient Information Leaflet]. Cape Town, South Africa: Cipla Medpro (Pty) Ltd.; 2022. [Accessed 06 Nov, 2025] (online) Available from:
Letairis (Ambrisentan) [Product Information]. [Accessed 09 Jun, 2023] (online) Available from:

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Steris Healthcare Pvt Ltd
Address: A.O. : 328-A, Tanaji Chowk, New Mill Road, Kurla (West), Mumbai 400070.

Vendor Details

Country of origin: India

Lab tests offered by us

Why we need a prescription?

Ambristar 5mg Tablet

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General Information

Contains

Marketer

Storage

Product introduction

Uses of Ambristar Tablet

Benefits of Ambristar Tablet

Side effects of Ambristar Tablet

How to use Ambristar Tablet

How Ambristar Tablet works

All substitutes for Ambristar 5mg Tablet

ENDobloc 5 Tablet

Ambrican 5 Tablet

Pulmonext 5 Tablet

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Rifampicin (Oral Route)

Rifampicin (Injection Route)

Ciclosporin (Oral Route)

Ciclosporin (Injection Route)

Conjugated Estrogens (Vaginal Route)

Frequently asked questions

Can Ambristar 5mg Tablet cause liver problems?

How should Ambristar 5mg Tablet be taken?

Can I stop taking Ambristar 5mg Tablet on my own?

What is the most important thing that I should know about Ambristar 5mg Tablet?

What are the serious side effects of Ambristar 5mg Tablet?

Why have I been prescribed Ambristar 5mg Tablet?

What are the symptoms of overdose of Ambristar 5mg Tablet?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

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