Volibris Tablet is a prescription medicine used to treat pulmonary arterial hypertension (high pressure in the blood vessels that carry blood from the heart to the lungs). It even helps to improve your quality of life, exercising ability and delay in disease progression.

Volibris Tablet may be taken with or without food but, it is better to take it in a dose and duration as advised by the doctor. In case, you have missed any dose than it is better to take another one as soon as you remember it.

The most common side effects of this medicine are peripheral edema, nasal congestion, sinusitis, and flushing. Let your doctor know if any of these side effects bothers you or persists for a longer duration. Dizziness may also occur in some people, so do not drive or do anything that requires mental focus if you experience such symptom.

Before receiving the treatment, inform your doctor if you are on any medication for any other health condition. Patients with liver or kidney disease must be cautious while receiving the prescription, and they must receive regular follow-ups as per the doctor’s advice.

Uses of Volibris Tablet

Pulmonary arterial hypertension (PAH)

Side effects of Volibris Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Volibris

Peripheral edema
Nasal congestion (stuffy nose)
Sinus inflammation
Flushing (sense of warmth in the face, ears, neck and trunk)

How to use Volibris Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Volibris Tablet may be taken with or without food, but it is better to take it at a fixed time.

How Volibris Tablet works

Volibris Tablet is an endothelin receptor blocker. It blocks the action of endothelin (a natural substance) that causes blood vessels to narrow (constrict). This narrowing increases the pressure in the blood vessels of the lungs. Volibris Tablet helps relax these blood vessels and increases the supply of blood to the lungs.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Volibris Tablet. Please consult your doctor.

Pregnancy

UNSAFE

Volibris Tablet is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.

Breast feeding

CONSULT YOUR DOCTOR

Information regarding the use of Volibris Tablet during breastfeeding is not available. Please consult your doctor.

Driving

CAUTION

Volibris Tablet may cause dizziness or weakness due to low blood pressure. Do not drive if these symptoms occur.

Kidney

CAUTION

Volibris Tablet should be used with caution in patients with severe kidney disease. Dose adjustment of Volibris Tablet may be needed. Please consult your doctor.
Limited information is available on use of Volibris Tablet in these patients. No dose adjustment is recommended in patients with mild to moderate kidney disease.

Liver

CAUTION

Volibris Tablet should be used with caution in patients with liver disease. Dose adjustment of Volibris Tablet may be needed. Please consult your doctor.

What if you forget to take Volibris Tablet?

If you miss a dose of Volibris Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.\n

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.

Volibris Tablet

₹239.4/Tablet

Ambrican 5 Tablet

Lupin Ltd

₹251.2/tablet

5% costlier

Endobloc 5 Tablet

Cipla Ltd

₹180.6/tablet

25% cheaper

Pulmonext 5 Tablet

MSN Laboratories

₹180.7/tablet

25% cheaper

Ibitan 5mg Tablet

Indiabulls pharmaceutical ltd

₹140.6/tablet

41% cheaper

Quick tips

Your doctor has prescribed Volibris Tablet to treat high pressure in the blood vessels that carry blood from the heart to the lungs (the pulmonary arteries).
It helps improve your quality of life, exercising ability, and delay disease progression.
Your doctor may ask you to get routine blood tests done to check for anemia and to assess the functioning of your liver.
Do not drive or do anything requiring concentration until you know how Volibris Tablet affects you.
Notify your doctor if you are pregnant or planning to conceive or breastfeeding.
Females with reproductive potential should use a reliable form of birth control while using and 1 month after stopping Volibris Tablet as it is toxic to an unborn baby.
Inform your doctor if you notice weight gain, swelling of your arms and legs, or difficulty breathing.
Your doctor has prescribed Volibris Tablet to treat high pressure in the blood vessels that carry blood from the heart to the lungs (the pulmonary arteries).
It helps improve your quality of life, exercising ability, and delay disease progression.
Notify your doctor if you are pregnant or planning to conceive or breastfeeding.
Your doctor may ask you to get routine blood tests done to check for anemia and to assess the functioning of your liver.
Do not drive or do anything requiring concentration until you know how Volibris Tablet affects you.
Inform your doctor if you notice weight gain, swelling of your arms and legs, or difficulty breathing.
Inform your doctor if you notice yellowing of skin/eye, dark urine, or stomach pain.

Fact Box

Chemical Class

Diphenylmethanes Derivative

Habit Forming

Therapeutic Class

CARDIAC

Action Class

Endothelin Receptor Antagonists (ERAs)

Interaction with drugs

Taking Volibris with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Ciclosporin (Oral Route) Moderate

Ciclosporin may raise blood levels of Ambrisentan. watch out for symptoms such as constipation, flushing or swelling under the skin and consult your doctor if you experience them.... More

Rifampicin (Oral Route) Moderate

Rifampicin may raise blood levels of Ambrisentan. Your doctor may monitor your treatment.

Rifampicin (Injection Route) Moderate

Rifampicin may raise blood levels of Ambrisentan. Your doctor may monitor your treatment.

Ciclosporin (Oral Route) Moderate

Ciclosporin may raise blood levels of Ambrisentan. watch out for symptoms such as constipation, flushing or swelling under the skin and consult your doctor if you experience them.... More

Conjugated Estrogens (Oral Route) Mild

Ambrisentan may raise blood levels of Conjugated Estrogens. Talk to your doctor if you notice any unusual symptoms.

View all drug interactions

Patient concerns

Hi my mother is prescibed : endobloc5 ta let So i want to ask is Volibris 5 mg tablet will suit her ? As she is suffering from low blood pressure and plumonary arterial problem

Dr. Vitrag Shah

Intensivist

Endobloc & volibris both have similar content, check it out. Amrisentan 5mg.

Having high Pulmonary Atrial Hypertension

Dr. Nabajit Talukdar

Cardiology

What medicines r u on

Hello Dr. My Dad is facing High Pulmonary Hypertension of 63 and average is 32. He has liver cirrhosis as well, he is advised for liver transplant. As the PAH is high cannot proceed with the surgery. Can you please advise if there is any way out. Age : 49yrs. Medicines for heart taken at present is : Ambrisentan 5mg Assurance 20mg Trimium Inhaler.

Dr. Nabajit Talukdar

Cardiology

Currently no other treatment apart from ambrisantan n assurance will have to wait n see response to medicines if pulmonary pressure comes down only then surgery possible

User feedback

Patients taking Volibris Tablet

Once A Day

92%

Twice A Day

What are you using Volibris Tablet for?

Pulmonary art*

100%

*Pulmonary arterial hypertension (PAH)

How much was the improvement?

Poor

67%

Average

33%

What were the side-effects while using Volibris Tablet?

No Side Effec*

100%

*No Side Effect

FAQs

Can Volibris Tablet cause liver problems?

Yes, Volibris Tablet commonly causes an increase in liver enzymes. It may rarely cause liver injury and inflammation of the liver because of the body’s own defences (autoimmune hepatitis). Consult your doctor if you have nausea, vomiting, loss of appetite, dark-colored urine and yellowing of the skin.

How should Volibris Tablet be taken?

Usually, the doctors advise to take one dose of Volibris Tablet. You can take it with or without food but prefer taking it at the same time each day. Swallow it whole with a glass of water. Do not crush, chew or break it into pieces.

Can I stop taking Volibris Tablet on my own?

No, you should not stop taking Volibris Tablet without consulting your doctor as this may worsen your condition. Talk to your doctor if you need to stop it.

What is the most important thing that I should know about Volibris Tablet?

Volibris Tablet may cause serious birth defects if taken during pregnancy. Therefore, every woman who is capable of becoming pregnant should get a pregnancy test done before starting Volibris Tablet. Additionally, during treatment with Volibris Tablet you should use two reliable methods of contraception to ensure that you do not get pregnant.

What are the serious side effects of Volibris Tablet?

The serious side effects of Volibris Tablet are swelling all over the body (fluid retention), decreased sperm count and low red blood cell count (anemia). Tell your doctor if you have any unusual weight gain, tiredness, or trouble breathing.

Why have I been prescribed Volibris Tablet?

Volibris Tablet is used to treat pulmonary hypertension in adults. Pulmonary hypertension is a condition wherein there is increased blood pressure in the pulmonary arteries (blood vessels that carry blood from heart to lungs). Volibris Tablet lowers the blood pressure by relaxing the pulmonary arteries, making it easier for the heart to pump blood through them.

What are the symptoms of overdose of Volibris Tablet?

Taking more than the recommended dose of Volibris Tablet may cause headache, flushing, dizziness, or nausea. It may cause low blood pressure which may further lead to lightheadedness. Contact your doctor immediately or seek emergency medical services in a nearby hospital if you take more than the recommended doses of this medicine.

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Disclaimer:

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

Barnes PJ. Pulmonary Pharmacology. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 1059.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 39-50.
Name of medicine. Citywest Business Campus Dublin: GlaxoSmithKline (Ireland) Limited; 2008 [revised 31 Oct. 2018]. [Accessed 01 Apr. 2019] (online) Available from:
Ambrisentan. Uxbridge, Middlesex: GlaxoSmithKline UK; 2008 [revised 31 Oct. 2018]. [Accessed 25 Jan. 2019] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 01 Apr. 2019] (online) Available from:
CiplaMed. Ambrisentan [Prescribing Information]. [Last reviewed: May 2018] [Accessed 09 Jun, 2023] (online) Available from:
(ambrisentan) [Product Information]. [Accessed 09 Jun, 2023] (online) Available from:

Marketer details

Name: Glaxo SmithKline Pharmaceuticals Ltd

Address: Dr. Annie Besant Road, Mumbai - 400 030

Country of origin: Canada

The list of available options shown with the same composition has been prepared upon the advice of registered medical practitioners, pharmacists affiliated with TATA 1MG. TATA 1MG does not promote any pharmaceutical product of any particular company, and all recommendations are based on the medical opinion, advisories from specialist medical and pharmaceutical professionals.