Hepatitis E Virus IgG Antibody
Understanding Hepatitis E Virus IgG Antibody
What is Hepatitis E Virus IgG Antibody?
The Hepatitis E Virus IgG Antibody is a blood test that detects Immunoglobulin G (IgG) antibodies against past Hepatitis E virus (HEV) infection. It helps determine if an individual has been exposed to HEV in the past and whether they have developed immunity to the virus.
Hepatitis E is an inflammation of the liver caused by infection with the hepatitis E virus (HEV). It is transmitted mainly through contaminated drinking water. HEV causes acute liver disease, which can lead to severe outcomes, especially in high-risk populations such as pregnant women, young children and individuals with weakened immune systems.
The Hepatitis E Virus IgG Antibody test is used to detect Immunoglobulin G (IgG) antibodies, which are produced by the immune system in response to a past HEV infection. These antibodies can remain in the bloodstream for years after the infection has resolved, indicating previous exposure and immunity. This test is especially useful for understanding whether you have had HEV in the past or whether you are protected against future infection, particularly in cases where symptoms are not present but past exposure is suspected.
Hepatitis E virus (HEV) infection often presents without symptoms, but when they do occur, they can vary from mild to severe. Common signs include a mild fever, reduced appetite (anorexia), nausea, vomiting lasting several days, abdominal pain, itching, skin rash, joint pain, jaundice (yellowing of the skin), dark urine, pale stools, and a slightly enlarged, tender liver (hepatomegaly). Your doctor may recommend the Hepatitis E Virus IgG Antibody test if you experience these symptoms, or if you have a history of exposure to HEV or are at higher risk due to liver disease or pregnancy.
No special preparation is required for this test. Inform the doctor about all the medications or supplements that you are taking as these factors can influence the test results.
Lab test results may vary across laboratories. Abnormal test results require an expert interpretation, therefore, never try to self-medicate at home based solely on these results, and always consult a doctor for proper understanding of the test results and appropriate follow-up care, which may include additional testing to monitor liver function and ensure recovery.
What is Hepatitis E Virus IgG Antibody used for?
The Hepatitis E Virus IgG Antibody test is done:
- To determine if an individual has been exposed to HEV in the past.
- To determine if an individual has developed immunity to HEV and to assess the risk of complications.
- When there are symptoms suggestive of HEV infection such as abdominal pain, itching, skin rash, joint pain, jaundice (yellowing of the skin), dark urine, pale stools, and a slightly enlarged, tender liver.
- To confirm the exposure to HEV, especially in individuals with known contact with contaminated food and water.
- To diagnose HEV infection in pregnant women, immunocompromised individuals, young children and travelers to hepatitis E endemic areas.
What does Hepatitis E Virus IgG Antibody measure?
The Hepatitis E Virus IgG Antibody test measures the presence of Immunoglobulin G (IgG) antibodies specific to the Hepatitis E virus in the blood. These antibodies indicate a past infection and the development of immunity as IgG antibodies are produced as a longer-term response to a previous HEV infection. This test helps confirm previous exposure to HEV and assess immune status for those who may have been infected or are at risk of future exposure.
Interpreting Hepatitis E Virus IgG Antibody results
Interpretations
The test results indicate presence or absence of an infection. If the results are reactive, an infection of Hepatitis E virus is present. If results are non reactive, there is no infection. Sometimes a borderline reactive result appears, indicating an old exposure to the virus, or a subsiding infection.