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ANA/ENA 18 Antigens, Qualitative Profile, Blot/LIA near me in Visakhapatnam

Also known as Autoimmune
ANA/ENA 18 Antigens, Qualitative Profile, Blot/LIA in Visakhapatnam Includes 18 testsView All
You need to provide
Blood
This test is for
Male, Female
Test Preparation
  1. No special preparation is required.

Understanding ANA/ENA 18 Antigens, Qualitative Profile, Blot/LIA in Visakhapatnam


What is ANA/ENA 18 Antigens, Qualitative Profile, Blot/LIA in Visakhapatnam?

Available at an affordable price in Visakhapatnam with Tata 1mg labs, an ANA/ENA 18 Antigens, Qualitative Profile, Blot/LIA detects specific antibodies or proteins called Antinuclear antibodies (ANAs) or autoantibodies. These antibodies, produced by the immune system, mistakenly attack healthy cells and tissues, leading to autoimmune disorders. This profile helps in diagnosing various autoimmune conditions, including systemic lupus erythematosus (SLE), Sjogren's syndrome, Rheumatoid arthritis (RA), Scleroderma, and other connective tissue disorders. 

This profile analyzes a panel of 18 antigens, including those associated with Extractable Nuclear Antigens (ENA), offering insights into the autoimmune response. Once ANA positivity is established, further testing with an ENA panel may be warranted using a method called line immunoassay (LIA) to qualitatively analyze antibodies against 18 specific antigens associated with autoimmune disorders. By identifying specific antigens associated with various autoimmune disorders, an ANA/ENA 18 Antigens, Qualitative Profile, Blot/LIA helps in categorizing and understanding the nature of the autoimmune response in an individual’s body. Overnight fasting of 8 to 12 hours is required for this test. However, drinking water is acceptable. 

What does ANA/ENA 18 Antigens, Qualitative Profile, Blot/LIA measure?

Contains 18 tests

An ANA/ENA 18 Antigens, Qualitative Profile, Blot/LIA helps screen autoantibodies in the blood of an individual. These antibodies react with proteins present inside the nucleus of the cell and cause autoimmune disorders. 

An ANA/ENA 18 Antigens, Qualitative Profile, Blot/LIA examines 18 different antigens, helping identify patterns related to autoimmune diseases. This comprehensive test helps in the diagnosis of conditions like Systemic Lupus Erythematosus, Sjogren’s Syndrome, mixed connective tissue disorders, or other autoimmune disorders by assessing the immune system’s activity and detecting the specific antibodies that may indicate an autoimmune response.

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SS-B/La

The SS-B/La measures the presence of antibodies against the SS-B antigen in the blood. These antibodies are often associated with autoimmune disorders, particularly Sjorgen's syndrome. This test is used alongside SS-A (Ro) antibody test to help in the diagnosis of Sjogren's syndrome and other autoimmune diseases like Systemic lupus erythematosus (SLE). Detecting SS-B antibodies helps doctors assess autoimmune activity, confirm diagnosis and differentiate between various autoimmune conditions. However, the presence of SS-B antibodies alone is not definitive, and results should be interpreted in conjunction with clinical symptoms and other laboratory findings.

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SS-A/Ro60

SSA-A/Ro52

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ds-DNA

The ds-DNA test detects the presence of antibodies specifically directed against the genetic material called double-stranded DNA (dsDNA) found in the nucleus of cells. These antibodies are often found in systemic lupus erythematosus (SLE), an autoimmune disease where the immune system mistakenly attacks its own DNA. A positive result means that these antibodies are present, suggesting active disease or flare-ups, especially in the kidneys. A negative result means the antibodies were not found, making SLE less likely but not ruling it out completely. This test helps doctors understand if the disease is active and monitor how well treatments are working.

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SmD1

The SmD1 test detects the presence of anti-Sm antibodies, often found in individuals with systemic lupus erythematosus (SLE), a type of autoimmune disease. The SmD1 test specifically helps doctors diagnose lupus, as these antibodies are highly specific to the disease. A positive result for anti-SmD1 antibodies, along with other clinical signs and symptoms, may help confirm the diagnosis of SLE. However, not everyone with lupus will have these antibodies, and they can sometimes be present in other conditions. On the other hand, a negative result means that these specific antibodies were not detected in the blood. While a negative result makes SLE less likely, it doesn't completely rule it out, as some individuals with lupus may not have detectable anti-Sm antibodies. 

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PCNA

The PCNA, (Proliferating Cell Nuclear Antigen) test detects antibodies against PCNA, a protein that plays a key role in DNA replication and repair. These antibodies are a rare type of antinuclear antibodies (ANA), considered highly specific for systemic lupus erythematosus (SLE), and connective tissue disorders but can also be found in viral infections, or tumors. A positive result for PCNA antibodies may suggest the presence of these autoimmune conditions. A negative result in the PCNA test means that no antibodies against the PCNA protein were detected in the blood suggesting a lower likelihood of autoimmune diseases. However, the test is not used alone for diagnosis and is typically considered alongside other clinical findings and tests to help confirm an autoimmune disorder.

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P0 (RPP)

The P0 (RPP), also known as the Ribosome P Protein antibody test, checks for antibodies that attack the P0, P1, and P2 proteins found in the 60S subunit of the ribosome. These proteins are important for making proteins inside cells. The presence of these antibodies is often seen in people with Systemic Lupus Erythematosus (SLE), especially those with neuropsychiatric symptoms like depression, confusion, or psychosis. The test is helpful for diagnosing neuropsychiatric lupus and can also indicate kidney problems in lupus patients.  A positive result suggests the presence of antibodies commonly associated with Systemic Lupus Erythematosus (SLE), while a negative result typically means these specific antibodies are not present, though it doesn’t rule out lupus or other conditions.

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DFS70

The (test_name), also Anti-Dense Fine Speckled Protein 70 (Anti-DFS70) test detects antibodies targeting the DFS70 protein in the blood. These antibodies are often linked to autoimmune disorders, such as Systemic Lupus Erythematosus (SLE) or Sjögren's Syndrome. However, Anti-DFS70 antibodies can also appear in healthy individuals. This test is useful in identifying individuals who do not have an ANA-associated Autoimmune Rheumatic Disease (AARD), particularly when there are no significant clinical symptoms. When Anti-DFS70 antibodies are positive in isolation (without other AARD-associated antibodies), it can help prevent unnecessary tests for individuals who test positive for ANA but do not have an autoimmune condition.

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Ku

The Ku antibody test is used to detect antibodies against the Ku protein, which is involved in DNA repair and other cellular processes. These antibodies are associated with certain autoimmune diseases, particularly systemic sclerosis, polymyositis and overlap syndrome such as MIxed Connective tissues disease( MCTD). This test is not commonly prescribed as other autoimmune tests but it is useful in diagnosing and differentiating between autoimmune conditions when patients presents with overlapping symptoms like muscle weakness, joint inflammation etc. The presence of Ku antibodies, along with clinical findings and other laboratory tests, helps doctors tailor treatment plans and better understand the patient's autoimmune profile.

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Mi-2

The Mi-2 test checks for the presence of autoantibodies that target the Mi-2 nuclear antigen, a protein involved in gene regulation and muscle function. This test is used to help diagnose idiopathic inflammatory myopathies, such as Dermatomyositis (DM) and Polymyositis (PM), which are autoimmune diseases that cause muscle weakness and skin rashes. A positive result indicates the presence of Mi-2 antibodies, suggesting one of these conditions. A negative result means that the antibodies are not found, making these diseases less likely, but it doesn't completely rule them out. Additional tests may be needed for a more accurate diagnosis.

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Scl-70

The Scl-70 test detects the presence of antibodies against the topoisomerase I enzyme, which plays a role in DNA replication and repair. The presence of these antibodies are associated with systemic sclerosis (SSc), also known as scleroderma. The test can help diagnose SSc, predict the risk of complications, and differentiate SSc from other similar autoimmune conditions. A positive test result suggests that the immune system may be attacking this enzyme, which can lead to tissue damage and fibrosis. A negative result typically means that these antibodies are not present, making systemic sclerosis less likely, though it doesn’t completely rule it out. Additional tests may be needed to confirm a diagnosis or explore other possible autoimmune conditions.

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PM-Scl

The PM-Scl test is used to detect antibodies against PM-Scl proteins, which are involved in the regulation of RNA and protein synthesis within cells. This test is primarily used to help diagnose Polymyositis (PM) and Systemic Sclerosis (SSc), specifically a form known as overlap syndrome, where symptoms of both diseases occur together. A positive result suggests the presence of these antibodies, which can indicate an autoimmune response affecting muscles, skin, and internal organs. A negative result means the antibodies are not detected, making these conditions less likely, though it doesn’t entirely rule them out. Additional tests may be needed to confirm the diagnosis or consider other autoimmune diseases.

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Jo-1

The Jo-1 test is used to detect antibodies against the JO-1 protein, which plays a role in muscle and tissue function. Jo-1 antibody is a myositis-specific autoantibody most commonly found in patients with idiopathic inflammatory myopathies (IIM). This test is primarily used to help diagnose IIM, particularly Dermatomyositis (DM) and Polymyositis (PM). It can be considered a specific marker of IIM, predominantly found in these conditions. The test is also associated with Interstitial Lung Disease (ILD), Raynaud phenomenon, arthritis, and mechanic's hands. A positive result suggests the presence of anti-synthetase syndrome (a rare autoimmune disease that affects multiple systems of the body) or a higher risk of myositis (muscle inflammation). A negative result means the antibodies are not detected, but it does not completely rule out the diagnosis of idiopathic inflammatory myositis. Further tests may be needed for a definitive diagnosis.

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Histones

The Histones test is used to detect antibodies against histones, which are proteins that help package DNA within cells. This test is primarily used to help diagnose drug-induced lupus, a form of lupus that is triggered by certain medications. The test can also be helpful in diagnosing Systemic Lupus Erythematosus (SLE), although it is more commonly seen in drug-induced lupus. A positive result suggests the presence of antibodies against histones, which can indicate an autoimmune response, often associated with lupus. A negative result means that histone antibodies are not detected, making drug-induced lupus or lupus less likely, though it doesn't completely rule out the condition. Further tests may be needed for a more accurate diagnosis.

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CENP-B

The CENP-B, also known as Centromere Protein B test is used to detect antibodies against the centromere protein CENP-B in the blood. This protein plays a role in cell division and is associated with certain autoimmune disorders. The test is primarily used to diagnose Systemic Sclerosis (SSc), including its specific form known as CREST syndrome (Limited Systemic Sclerosis). A positive result suggests the presence of these antibodies, helping doctors confirm a diagnosis of scleroderma or CREST syndrome. A negative result means that these antibodies are not found, making these conditions less likely, but it doesn't completely rule them out. In some cases, further testing may be needed to confirm the diagnosis.

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Nucleosomes

The Nucleosomes test detects the presence or absence of antibodies against nucleosomes, which are structures made of DNA and proteins found in the nucleus of cells. These antibodies are often linked to autoimmune diseases, especially systemic lupus erythematosus (SLE) and drug-induced lupus. A positive result means that these antibodies are present in the blood, which may indicate an autoimmune response. A negative result in the qualitative nucleosome test means that no antibodies against nucleosomes were detected in the blood. This suggests that the person is less likely to have an autoimmune disease. However, it doesn't completely rule out other autoimmune conditions or the possibility of the disease developing later. 

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U1-snRNP

The U1-snRNP, also known as (U1 small nuclear ribonucleoprotein) test is used to detect antibodies against the U1-snRNP, a group of proteins involved in the process of RNA splicing, which is essential for proper cell function. This test helps diagnose rheumatic diseases such as mixed connective tissue disease (MCTD), and systemic lupus erythematosus (SLE). This test also helps doctors differentiate MCTD from other similar illnesses, making it easier to understand the specifics of the autoimmune response. A positive result suggests that the immune system may be attacking these proteins, leading to inflammation and potential tissue damage. The U1-snRNP test is often used when a doctor suspects an autoimmune disease and needs more specific information to confirm the diagnosis. 

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AMA-M2

The AMA-M2 test detects the presence of anti-mitochondrial antibodies (AMAs) that play a critical role in the context of primary biliary cholangitis (PBC), a chronic liver disease. These autoantibodies target specific proteins in the mitochondria and are found in approximately 95% of individuals suffering from PBC, making them highly specific for the disease. A positive AMA-M2 test result suggests that the body is producing antibodies against these mitochondrial proteins, which can help confirm a PBC diagnosis. On the other hand, a negative result generally indicates that PBC is unlikely, although it doesn't completely rule out other liver conditions. 

 

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Answers to Patient Concerns & Frequently Asked Questions (FAQs) about ANA/ENA 18 Antigens, Qualitative Profile, Blot/LIA in Visakhapatnam


Frequently Asked Questions about ANA/ENA 18 Antigens, Qualitative Profile, Blot/LIA in Visakhapatnam

Q. Why is the purpose of an ANA/ENA 18 Antigens, Qualitative Profile, Blot/LIA?

An ANA/ENA 18 Antigens, Qualitative Profile, Blot/LIA helps detect specific antibodies in your blood, helping in the diagnosis of autoimmune diseases such as lupus, Sjogren’s Syndrome, mixed connective tissue disorders, and others.

Q. Why is an ANA/ENA 18 Antigens, Qualitative Profile, Blot/LIA done?

An ANA/ENA 18 Antigens, Qualitative Profile, Blot/LIA is done to identify autoimmune disorders, especially when individuals exhibit symptoms like joint pain, fatigue,light sensitivity or skin rashes. It aids in early detection and guides appropriate treatment.

Q. Is there any risk associated with an ANA/ENA 18 Antigens, Qualitative Profile, Blot/LIA?

No, there is no risk associated with an ANA/ENA 18 Antigens, Qualitative Profile, Blot/LIA. However, some individuals may feel a slight sting when a needle is pricked and experience some bleeding that is normal and usually not bothersome. Rarely, some individuals may also experience slight swelling or bruising at the site of the needle prick. Applying ice 3-4 times a day for about a week may help reduce swelling and bruising. If it does not get better, consult your doctor.

Q. Can I schedule an ANA/ENA 18 Antigens, Qualitative Profile, Blot/LIA online in Visakhapatnam near me?

Yes. In Visakhapatnam, you can schedule the ANA/ENA 18 Antigens, Qualitative Profile, Blot/LIA test near you with Tata 1mg Labs. The profile is easy to book, cost-effective, and available with a comprehensive report.

Q. Is home sample collection facility available for an ANA/ENA 18 Antigens, Qualitative Profile, Blot/LIA in Visakhapatnam with Tata 1mg Labs?

Yes, home sample collection for an ANA/ENA 18 Antigens, Qualitative Profile, Blot/LIA is readily available in Visakhapatnam. Tata 1mg Labs allows you to choose a date and time that suits your schedule for sample collection.

Q. How can I schedule an ANA/ENA 18 Antigens, Qualitative Profile, Blot/LIA with Tata 1mg Labs in Visakhapatnam?

If you want to schedule an ANA/ENA 18 Antigens, Qualitative Profile, Blot/LIA with Tata 1mg Labs in Visakhapatnam, the procedure is fairly easy and hassle-free. Follow these steps to book a test: 1). Visit the Lab Tests section on the Tata 1mg website. 2). Add the test you want in the cart. 3). Pick a time and date slot according to your convenience; however, do consider the necessary prerequisites while scheduling a test. 4). You will receive a notification with all the details once the test is scheduled.

Q. What is the cost of an ANA/ENA 18 Antigens, Qualitative Profile, Blot/LIA at Tata 1mg Labs in Visakhapatnam?

Tata 1mg Labs is a pocket-friendly platform for booking lab tests in Visakhapatnam. An ANA/ENA 18 Antigens, Qualitative Profile, Blot/LIA is available at an affordable price of Rs. 5128.

Q. How long does Tata 1mg Labs take to give the reports of an ANA/ENA 18 Antigens, Qualitative Profile, Blot/LIA in Visakhapatnam?

At Tata 1mg Labs, we understand the importance of timely results. We strive to provide fast turnaround times for test results, allowing you to get the information you need promptly. On average, we take 96 hours to provide the reports of an ANA/ENA 18 Antigens, Qualitative Profile, Blot/LIA in Visakhapatnam.
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ANA/ENA 18 Antigens, Qualitative Profile, Blot/LIA test price for other cities


Price inBangaloreRs. 5128
Price inHyderabadRs. 5128
Price inNew DelhiRs. 5128
Price inMumbaiRs. 5128
Price inKolkataRs. 5128
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References

  1. Phan TG, Wong RC, Adelstein S. Autoantibodies to extractable nuclear antigens: making detection and interpretation more meaningful. Clin Diagn Lab Immunol. 2002 Jan;9(1):1-7. [Accessed 21 Mar. 2024]. Available from: https://docs.google.com/document/d/10Ui0ZEge61oVKN3rN87YN2NOrmCJ4lkCXtMsAqWQ8-M/edit External Link
  2. Overview of Systemic Lupus Erythematosus (Lupus) [Internet]. NIH; Oct. 2022. [Accessed 21 Mar. 2024]. Available from: https://www.niams.nih.gov/health-topics/lupus External Link
  3. Kumar Y, Bhatia A, Minz RW. Antinuclear antibodies and their detection methods in diagnosis of connective tissue diseases: a journey revisited. Diagn Pathol. 2009 Jan 2;4:1. [Accessed 21 Mar. 2024]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2628865/ External Link
  4. Nosal RS, Superville SS, Amraei R, et al. Biochemistry, Antinuclear Antibodies (ANA) [Updated 2022 Dec 29]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK537071/ External Link
  5. Tešija Kuna A, Đerek L, Drvar V, Kozmar A, Gugo K. Assessment of antinuclear antibodies (ANA): National recommendations on behalf of the Croatian society of medical biochemistry and laboratory medicine. Biochem Med (Zagreb). 2021 Jun 15;31(2):020502. [Accessed 21 Mar. 2024]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8047791/ External Link
  6. Venables PJ, Erhardt CC, Maini RN. Antibodies to extractable nuclear antigens in rheumatoid arthritis: relationship to vasculitis and circulating immune complexes. Clin Exp Immunol. 1980 Jan;39(1):146-53. PMID: 6771070; PMCID: PMC1537954. [Accessed 21 Mar. 2024]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1537954/ External Link
  7. Grygiel-Górniak B, Rogacka N, Puszczewicz M. Antinuclear antibodies in healthy individuals and non-rheumatic diseases - diagnostic and clinical implications. Reumatologia. 2018;56(4):243-248. [Accessed 21 Mar. 2024]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142026/ External Link
  8. Li QZ, Karp DR, Quan J, Branch VK, Zhou J, Lian Y, Chong BF, Wakeland EK, Olsen NJ. Risk factors for ANA positivity in healthy persons. Arthritis Res Ther. 2011 Mar 2;13(2):R38. [Accessed 21 Mar. 2024]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132017/ External Link
  9. Cojocaru M, Cojocaru IM, Silosi I, Vrabie CD. Manifestations of systemic lupus erythematosus. Maedica (Bucur). 2011 Oct;6(4):330-6. PMID: 22879850; PMCID: PMC3391953. [Accessed 21 Mar. 2024]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3391953/ External Link

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